| 车立刚,陈文才,杨恒林,黄开国.云南恶性疟抗氯喹株地理分布调查报告[J].Chinese journal of Epidemiology,1986,7(2):88-91 |
| 云南恶性疟抗氯喹株地理分布调查报告 |
| A Survey of Geographical Distribution of Chloro-quinine-Resistant Strains of Malignant Malaria in Yunnan Province |
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| Abstract: |
| 采用WHO推荐的体外微量测定法和临床观察法,调查云南恶性疟抗氯喹株地理分布,证实云南省西南边境一线,恶性疟对氯喹的抗性程度很高,抗性率在96.0%以上,Ⅱ、Ⅲ级抗性在半数以上,半数有效量在6.9微微克分子/孔以上;滇中地区抗性程度低,临床观察未发现抗性病例,体外测定半数有效量为2.55微微克分子/孔;边境与滇中地区之间的地带,抗性程度居于两地区之间。 |
| English Abstract: |
| By means of Micro-determination in Vitro recommended by WHO and Clinical observation, an investigation of the geographical distribution of drug (Chloroquinine)-resistant strains of P. falciparum in Yun nan Provincs was made. It was revealed that in the south-west of Yunnan boarder-line, the resistance of malignant malaria to Chloro quinine therapy was very high, the incidance Was higher than 96%, Ⅱ & Ⅲ degrees being higher than 50%. 50% effective dose over 6.9ngmol/hole; In the Central Area of Yunnan, the degree of drug resistance was low. No drug-fast clinical case was revealed. 50% Effective dose determined in vitro was found to be 2.55ng/hole. The median District between the boarder-line and that of Central Yunnan, the degree of drug Resistance being the median range of the above two levels. |
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