广州地区单纯疱疹病毒和巨细胞病毒抗体的年龄分布

常汝虚; 关启鸿; 林全胜

Abstract

常汝虚,关启鸿,林全胜.广州地区单纯疱疹病毒和巨细胞病毒抗体的年龄分布[J].Chinese journal of Epidemiology,1986,7(5):257-260

广州地区单纯疱疹病毒和巨细胞病毒抗体的年龄分布

The Distribution of Herpes Simplex and Cytomegalovirus Antibody in Different Age Group in Guangzhou

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Author Name	Affiliation
Chang Ru-Xu	Guangzhou Children's Hospital and Jinan University Medicul College, Guangzhou
关启鸿	Guangzhou Children's Hospital and Jinan University Medicul College, Guangzhou
林全胜	暨南大学医学院

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Abstract:

采集广州各年龄组280份血清,用同一份血清作单纯疱疹病毒1型(HSV₁),单纯疱疹病毒2型(HSV₂)和巨细胞病毒(CMV)的补体结合试验。≤6月龄的HSV₁和HSV₂的补体结合抗体阳性率分别为70.6%和61.8%,至6~12月龄时下降,1岁以上至6岁因陆续受到感染而抗体阳性率有所上升,7岁组的HSV₁和HSV₂的抗体阳性率分别为71.0%和58.1%,14岁以上至成人组分别为93.3%和86.7%。≤6月龄婴儿的CMV抗体阳性率为73.5%,7~12月龄的抗体阳性率没有下降,反而上升至83.9%。1岁以上至6岁之间阳性率为41.9%~58.1%。7至8岁组上升至83.9%,14岁以上至成人组为86.7%。HSV和CMV抗体几何平均滴度与阳性率变动相一致。研究结果指出HSV和CMV的感染普遍。7~12月龄CMV感染率的上升主要由于母亲传给婴儿。

English Abstract:

280 serum samples from different age groups in Guangzhou were examined for the presence of complement-fixing (CF) antibody to herpes simplex virus type 1 (HSV1), herpes simplex virus type 2 (HSV2) and eytomegalovirus (CMV). It revealed that 70.6% and 61.8% of infants less than 6 months of age possessed HSV1 and HSV2 antibody respectively. The percentage of detectable antibody decreased by the age of 6-12 months and increased subsequantly by the age of ﹥1-6 years. 71.0% and 58.1% of children aged 7-8 years were found to have HSV1 and HSV2 CF antibody respectively. 93.3% of adults possessed HSV1 CF antibody while 86.7% of them possessed antibody of HSV2. Examination for CMV revealed that 73.5% of infants less than 6 months of age Possessed CMV CF antibody. The Percentage of detectable serum antibody did not decrease by the age of 7-12 months, it approached to 83.9% conversely. After that, the prevalence of detectable CMV antibody ranged from 41.9 to 68.1% by the age of ﹥1-6 years. 83.9% of children aged 7-8 years were shown to have CMV CF antibody and it reached 86.7% in adults. The geometric mean titers of HSV1, HSV2 and CMV CF antibody correlated with the rate of antibody positivity.
Results obtained indicate the prevalent infection of HSV1, HSV2 and CMV in the investigated area and the high prevalence of CMV antibody by the age of 7-12 months suggests most CMV infection might be transmitted from mother to infant during early life.

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