| 黄永年,王丽娜,骆洪钧,聂爱光,李岩.从腹泻病人粪便中检出冠状病毒的报告[J].Chinese journal of Epidemiology,1987,8(1):25-27 |
| 从腹泻病人粪便中检出冠状病毒的报告 |
| A Finding of Coronavirus Particles in Feces of patients with Diarrhea |
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| Abstract: |
| 1984年春,吉林省东丰县田家街屯发生了一起腹泻病的爆发流行。流行病学调查结果表明,这是一起由于接触传染引起的流行性腹泻病。在疫区采集的10份患者粪便均查到了冠状病毒样颗粒;而20份对照样品未查到病毒样颗粒。9/10的患者双份血清的补体结合抗体效价有4倍或4倍以上的增长;而20份对照样品为阴性。这些结果说明,冠状病毒是引起这次疫情爆发的病原体。 |
| English Abstract: |
| An outbreak of epidemic diarrhea occurred during March-April period in 1984 at a village of Donfong County of Jilin Province. 10 fecal samples as well as 10 paired sera from clinical cases were collected and other 20 fecal samples as well as 20 seram samples from healthy individuals in the village were used as controls. Coronavirus-like particles were seen in all the fecal samples collected from acute cases using electron microscopy but not in control samples. The coronavirus-like particles were aggregated by convalescent-phase sera in immune electron microseopy. The micro complement fixation test using specific extracted antigen was carried out. 9 out of 10 paired sera from the patients showed 4-fold or more increase titre while sera from healthy controls were negative. |
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