| 李东光,乔树民,田忠厚,高晓虹.硒及锌、铜元素与胃癌关系的初步探讨[J].Chinese journal of Epidemiology,1987,8(5):276-280 |
| 硒及锌、铜元素与胃癌关系的初步探讨 |
| A Preliminary Investigation on the Role of Selenium and Other Trace Elements in the Pathogenesis of Gastric Cancer |
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| DOI： |
| KeyWord: 硒 锌 铜 微量元素 土壤酸度 胃癌 病因学 |
| English Key Word: Selenium Zinc Copper Trace element Acidity of soil Gastric cancer Etiology |
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| Abstract: |
| 本文对选定的胃癌高、低发区土壤、粮食硒含量做了测定和分析,未发现其含量在胃癌高、低发区间有显著差别。认为硒与胃癌并非简单因果联系。对选定地区胃癌患者与对照者发硒含量测定与分析提示胃癌患者体内低硒可能是患癌结果而非原因。又对该地区土壤锌、铜含量及酸度等与胃癌关系做了探索,发现上述因素均表现为高发区显著高于低发区,为进一步研究胃癌有关因素提供了线索。 |
| English Abstract: |
| Starting from reassurance of the areas with high and low gastric cancer mortalities by personal house to house canvass, the soil Se, Cu, Zn and corn-Se concentration in both areas had been sampled and determined. It was found that there were no consistent associations between the Se concentrations in environmental soil or cereals and the mortality of gastric cancers. Then a simple and direct inference to regard Se deficiency as an etiologic factor of stomach cancer was apparently not correct. However, it was disclosed in this survey that the concentration of Zn, Cu and the acidity of soils are significantly higher in the high gastric cancer mortality areas than in low areas. These. differences might be relevant to or interfering with antitumour role, if any, of Se, and might provide a lead for further investigation into the complex webb of cancer causation. The determination and comparison of hair Se levels for the selected patients and controls in both areas suggested that the low Se status in patients' body occured after they had suffered from gastric cancer and seems to be a result of cancer development rather than a causative factor. |
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