| 刘铁甫,何尚浦,施侣元,张余庆,邹时勉,万受兰,张惠娟,王惠堂,姜清钊,姚连君,曲斌.HBV血清学标记携带者转归及其影响因素[J].Chinese journal of Epidemiology,1988,9(5):274-277 |
| HBV血清学标记携带者转归及其影响因素 |
| Conversion of HBV Serological Marker Carriers and Its Influential Factors |
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| DOI： |
| KeyWord: 携带状态 乙型病毒性肝炎 随访研究 多因素分析 |
| English Key Word: Carrier state Viral hepatitis B Follow up study Multivariate analysis |
| FundProject: |
| Author Name | Affiliation | | Liu Tiepu | Department of Epidemiology, Tongji Medical University, Wuhan | | 何尚浦 | Department of Epidemiology, Tongji Medical University, Wuhan | | 施侣元 | Department of Epidemiology, Tongji Medical University, Wuhan | | 张余庆 | Department of Epidemiology, Tongji Medical University, Wuhan | | 邹时勉 | Department of Epidemiology, Tongji Medical University, Wuhan | | 万受兰 | Department of Epidemiology, Tongji Medical University, Wuhan | | 张惠娟 | Department of Epidemiology, Tongji Medical University, Wuhan | | 王惠堂 | 湖北省钟祥县官庄湖农场职工医院 | | 姜清钊 | 湖北省钟祥县官庄湖农场职工医院 | | 姚连君 | 湖北省钟祥县官庄湖农场职工医院 | | 曲斌 | 湖北省钟祥县官庄湖农场职工医院 |
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| Abstract: |
| 本研究通过对HBV血清学标记携带者进行3年随访发现,3年后HBsAg和抗-HBc二标记阴转率为40.27%,3年后HBsAg、抗-HBc、HBeAg和抗-HBe四标记阴转率为30.62%。抗-HBs阳性有助于阴转,阴转率比为1.32,其效应受抗-HBc携带状况所修饰。HBsAg阳性者四标记阴转率有降低趋势。抗-HBc阳性者阴转率低,并且随着携带抗-HBc滴度越高,阴转率越低。文化水平和年龄与阴转呈负相关。进一步研究不同年龄携带者阴转率的差异有助于阐明HBV血清学标记携带者阴转规律及机理。 |
| English Abstract: |
| 485 HBV serological marker carriers were followed up for three years. The three years' negative conversion rate of both HBsAg and Anti-HBc in carriers was 40.27%. Four markers negative conversion rate of HBsAg, Anti-HBc, HBeAg and Anti-HBe was 30.62% after three years observation. Positive in Anti-HBs is helpful for negative conversion, ratio of negative conversion rates between Anti-HBc positive and negative is 1.32. But the effect of Anti-HBs was modified by Anti-HBc carriage. Negative conversion rate of Anti-HBc carriers was lower, and the higher the Anti-HBc titre, the lower the rate of negative conversion. Educational level and age were negatively correlated with conversion. |
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