红细胞膜Na<sup>+</sup>泵缺陷与原发性高血压:多元条件Logistic回归分析

李洪星; 金宝相; 廖建岗; 尹建强; 熊化保

Abstract

李洪星,金宝相,廖建岗,尹建强,熊化保.红细胞膜Na⁺泵缺陷与原发性高血压:多元条件Logistic回归分析[J].Chinese journal of Epidemiology,1989,10(2):98-101

红细胞膜Na⁺泵缺陷与原发性高血压:多元条件Logistic回归分析

A Study on the Relationship between Reduced Activity of Red Cell Membrane Sodium-Potassium Pump and Essential Hypertension

DOI：

KeyWord: 原发性高血压红细胞膜Na⁺泵条件Logistic回归分析

English Key Word: Essential hypertension Red cell membrame sodium potassium pump Conditional logistic regression

FundProject:

Author Name	Affiliation
Li Hongxing	Dept. of Public Health, Nanjing Railway Medical College
金宝相	Dept. of Public Health, Nanjing Railway Medical College
廖建岗	Dept. of Public Health, Nanjing Railway Medical College
尹建强	Dept. of Public Health, Nanjing Railway Medical College
熊化保	Dept. of Public Health, Nanjing Railway Medical College

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Abstract:

1986年在某工厂对红细胞膜Na⁺泵缺陷与原发性高血压的关系进行了103对配比调查。资料分析采用了条件Logistic回归分析方法。本研究提示RBCNa⁺的增高,RBCK⁺及RBCNa⁺,K⁺ATP-ase活性的降低与高血压有显著的联系;血浆Na⁺与体重这两个高血压的重要危险因素均与RBCNa⁺,K⁺ATPase活性的降低有关,提出红细胞膜的Na⁺泵功能缺陷可能是这两个因素对高血压的共同作用环节。

English Abstract:

A population-based matched study of 103 pairs on the relation of sodium-potassium pump defect and hypertension was conducted at a factory in 1986.Conditional Logistic regression technique was used in data analysis.It was suggested that the increase of RBCNa⁺ and decrease of RBCK⁺ and RBCNa⁺, K⁺ ATP-ase were significantly associated with hypertension.Plasma sodium and body weight. which were considered as important risk factors of hypertension, were fund correlated with the decrease of RBCNa⁺, K⁺ ATPase, it was proposed that reduced activity of cell membrane sodium-potassium pump might be the common link of the two factors with hypertension.

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