| 曾剑平,刘国璋,耿锦宁,蔡克利.无症状HBsAg携带者血游离HBV-DNA动态变化的流行病学意义[J].Chinese journal of Epidemiology,1989,10(6):328-330 |
| 无症状HBsAg携带者血游离HBV-DNA动态变化的流行病学意义 |
| Epidemiologic Significance of Persistent Observation of Serum HBV-DNA in Asymptomatic HBsAg Carriers |
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| DOI： |
| KeyWord: 无症状HBsAg携带者 HBV-DNA |
| English Key Word: Asymptomatic HBsAg Carriers (ASC) HBV-DNA |
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| Abstract: |
| 本文对65例无症状HBsAg携带者(ASC)的血清乙型肝炎病毒脱氧核糖核酸(HBV-DNA)进行了1~2年随访观察,并对不同HBV-DNA动态变化类型ASC的e抗原、DNA多聚酶(DNAP)、乙肝病毒表面抗原多聚白蛋白受体(HBsAg-PHSA-R)等乙肝病毒(HBV)复制标志及肝功能作了检查和比较,对部分ASC的家庭成员HBV感染情况作了调查。结果表明,在ASC中存在着传染性强的HBV-DNA持续阳性者27例(41.54%)、传染性弱的HBV-DNA持续阴性者21例(32.31%)、HBV-DNA阳转阴10例(15.38%)和阴转阳7例(10.77%)。其在流行病学上具有不同的意义。 |
| English Abstract: |
| Serum HBV-DNA was assayed in 65 asymptomatic HBsAg carriers (ASC) for one to two years.HBV replication marks, such as serum HBeAg, DNA polymerase, HBsAg-PHSA-R and liver function in the ASC with different types of the dynamic changes of HBV-DNA were determined and compared. The transmissive state in the family members of the ASC were investigated. The results showed that among the 65 ASC 27 cases (41.54%) were HBV-DNA persistently positive with marked infectivity, 21 cases (32.31%) were HBV-DNA persistently engative with lower infectivity 10 cases (15.38%) with HBV-DNA conversion from positive to negative and 7 cases (10.77%) with HBV-DNA conversion from negative to positive. It is of instructive significance in epidemiology. |
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