| 张桂宁,徐爱强,林玉纯.人类乳头瘤病毒与宫颈癌关系的研究[J].Chinese journal of Epidemiology,1990,11(1):31-33 |
| 人类乳头瘤病毒与宫颈癌关系的研究 |
| A Study on the Relationship between Human Papilloma Virus (HPV) and Cervical Cancer |
| Received:January 06, 1989 Revised:March 15, 1989 |
| DOI： |
| KeyWord: 宫颈癌 人类乳头瘤病毒 DNA相关序列 核酸杂交技术 |
| English Key Word: Cervical cancer Human papilloma virus (HPV) DNA related sequences Nucleic acid hybridization |
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| Abstract: |
| 用Southern blot核酸杂交技术检测宫颈组织HPV 16 DNA相关序列。山东省116例宫颈癌病人的癌组织HPV 16 DNA相关序列阳性率为50.9%,36例无宫颈疾病妇女的宫颈组织阳性率为5.6%,宫颈癌与HPV 16有强的联系。OR=17.60,χ2=23.47,P<0.01。HPV 16 DNA相关序列阳性率与宫颈癌病人的年龄、肿瘤的组织类型、临床类型及临床分期均无统计学上联系(P均大于0.25)。本文首次从山东省宫颈癌病人组织中检测到HPV 33 DNA 4例及HPV 31 DNA 1例。 |
| English Abstract: |
| Samples of cervical tissues of patients from Shandong prevince were detected by using Southern blot hybridization technique of nucleic acid with the probe of (α-2P)-dCTP HPV16 DNA fragment cleaving with BamHI. The total positive rate of HPV16 DNA related sequences in 116 cases with cervical cancer was 50.9%,and much higher tkan that in 36 cases with non-cervical disease (5.6%). There is a strong correlation between the HPV and cervical cancer (OR^IT.BO, P<0.001). It was showed that there was no association between the positive rate of HPV 16 DNA related sequences and age, clinical period and local appearance in cases with cervical cancer. This was the first pa per described that HPV 33 DNA sequences were found in four cervical carcinoma samples, and HPV 31 DNA sequence in one cervical carcinoma sample under low stringent conditions of hybridization in Shandong province. |
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