| 苏万年,范瑛,王福平,陈海平,刘金莲,董春明,周金福,李湘生,谈忠良,宋华章,冷红英,刁连东,张义煌,张荣珍,迮文远.脊髓灰质炎疫苗免疫的研究 Ⅱ.不同剂型的脊髓灰质炎疫苗免疫应答的比较[J].Chinese journal of Epidemiology,1991,12(5):284-285 |
| 脊髓灰质炎疫苗免疫的研究 Ⅱ.不同剂型的脊髓灰质炎疫苗免疫应答的比较 |
| A Study on Immunization of Polio Vaccine Ⅱ. Comparation of Responses Obtained by Different Forms of Polio Vaccine |
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| DOI： |
| KeyWord: 脊髓灰质炎疫苗 糖丸疫苗 液体疫苗 |
| English Key Word: Polio vaccine Polio dragee candy Vaccine Polio liquid vaccine |
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| Abstract: |
| 在江苏武进县农村对2~6月龄未服过脊髓灰质炎疫苗易感儿中,比较液体Ⅰ型,糖丸Ⅰ型和三价糖丸疫苗免疫应答。3种疫苗3次免疫后,抗体阳转率均达到95~100%,无统计学显著性差异,抗体几何平均滴度以液体Ⅰ型最高,液体Ⅰ型与糖丸Ⅰ型、Ⅰ型糖丸与三价糖丸无显著性差异,但三价糖丸与液体Ⅰ型相比有显著性差异。鉴于2~4月龄婴幼儿服用糖丸十分不便,且不易保证服苗效果,建议生产厂家克服困难创造条件尽快将脊灰糖丸剂型改为液体剂型。 |
| English Abstract: |
| A comparation study on the responses to the immunization of three different forms of polio vaccine, eg.Liquid I, Oral dragee candy I and Trivalent Oral dragee candy, on the susceptible children of 2~6 month of age was conducted in wujin County, Jiangsu Province The study showed no statistical difference between the responses to the three forms of the vaccine reaching 95~100%. For antibody GMT, Liquid I was the hightest, with little difference between Liquid I and Oral dragee candy I and Trivalent Oral dragee candy vaccine in statistics.But, there was a significant statistical difference between Trivalent Oral dragee candy and Liquid I. Considering that it is not easy to inoculate the children of 2~4 month of age with oral dragee candy vaccine, it is suggested all the producers try their best to convert the present oral dragee candy form into Liquid. |
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