| 汤永康,付桂明,魏亚南,何粟海,姜理平,陈越土,兰景清,王黎虹,俞年生,王素珍,俞樟友.“浙江丁型”钩端螺旋体菌苗接种后反应与免疫效果的现场研究[J].Chinese journal of Epidemiology,1991,12(6):335-338 |
| “浙江丁型”钩端螺旋体菌苗接种后反应与免疫效果的现场研究 |
| A Field Study on the Post-inoculation Reaction and Immunological Effects in Vaccinated Population Immunized with “Zhejiang Type-D” Leptospiral Vaccine |
| Received:January 20, 1990 Revised:April 06, 1990 |
| DOI： |
| KeyWord: 钩体菌苗 接种反应 免疫效果 |
| English Key Word: Leptospiral vaccine Postimmunization reaction Immunological effect |
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| Abstract: |
| 对人群接种不同剂量的“浙江丁型”钩体菌苗后,两剂量组(1ml、2ml)均未出现全身反应。局部反应,2ml组的中、重反应高于1ml组。免疫后一个月,2ml组抗体高于1ml组;免疫后三个月,七日热型1ml组抗体高于2ml组。1ml组黄疸出血型免后一、三个月抗体GMT≥4价普通菌苗和4价纯化外膜菌苗。阳转率免疫后一个月,黄疸出血型1ml组为73.08%,2ml组为86.10%,七日热型分别为58.55%和67.46%。免后三个月两组均有一定数量的人体抗体阴转,但无显著性差异。菌苗接种与否与发病关系:无接种史的发病率为226.70/10万(9/3970),2ml组为160.00/10万(1/625),1ml组免疫人群无病例发生,认为用1ml免疫人群可获得相同的保护作用。 |
| English Abstract: |
| A comparative study on the post-inoculation and anti-body responses after inoculation with two different dosage (1ml, 2ml) of "zhejiang type-D" leptospiral vaccine was carried out. There was no general reaction in all of the vaccinated people after immunization. The GMT values of antibody against leptospire were 3.08~7.91 times in 1ml dose group and 3.48~9.57 times in 2ml dose group more than pre-vaccination respectively. 3 months after immunization the levels of specific antibody still were high in most vaccinated people, whatever in 1ml dose or 2ml dose of immunization. However the antibody couldn't be detected in part of vaccinated people at that time, but there was no difference between the two different dosages. During the epidemic season, there was no leptospirosis case (0/3260) in the 1ml group, 1 case (1/625)in the 2ml group while there was 9/3970 in the control group. |
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