吸烟对健康人血清HDL-C等7项指标水平影响的对比观察

张堉; 郑诚东; 张代民; 赵耀华

Abstract

张堉,郑诚东,张代民,赵耀华.吸烟对健康人血清HDL-C等7项指标水平影响的对比观察[J].Chinese journal of Epidemiology,1992,13(2):97-100

吸烟对健康人血清HDL-C等7项指标水平影响的对比观察

Influence of Smoking on Cholesterol Concentrations in Serum Lipo-protein of Healthy Subjects

Received:March 07, 1990 Revised:June 30, 1990

DOI：

KeyWord: 吸烟高密度脂蛋白胆固醇低密度脂蛋白胆固醇极低密度脂蛋白胆固醇

English Key Word: Smoking HDL-C LDL-C VLDL-C

FundProject:

Author Name	Affiliation
Zhang Yu	Department of Epidemiology, Linyi Medical School, Shandong
郑诚东	Department of Epidemiology, Linyi Medical School, Shandong
张代民	解放军第88医院
赵耀华	铁道部十四局四处医院

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Abstract:

经对生活和工作环境相似的40~69岁健康男性工人吸烟组697人和不吸烟组841人的对比观察,说明吸烟对健康人血清脂蛋白组分胆固醇水平有明显影响。吸烟组HDL-C、HDL₂-C、HDL₃-C、HDL₂-C/HDL₃-C明显低于不吸烟组,LDL-C、VLDL-C、LDL-C/HDL-C明显高于不吸烟组,且与吸烟量、时间、习惯呈剂量反应关系。吸烟是降低HDL-C、HDL₂-C、HDL₃-C、HDL₂-C/HDL₃-C和升高LDL-C、VLDL-C、LDL-C/HDL-C的危险因素。与不吸烟组相比,吸烟降低HDL-C等4项指标水平和升高LDL-C等3项指标水平的RR分别为1.09~5.77和2.37~3.59。被动吸烟者HDL-C等7项指标水平与轻度吸烟者相似,说明被动吸烟对血清脂蛋白组分胆固醇有明显影响。

English Abstract:

Sixty hundred and nineteen-seven smokers and 841 non-smokers among healthy male workers of 40~60 years of age were comparatively observed. Their housing environment and working conditions were similar.The results showed that smoking had remarkable influence on the cholesterol concentration in the serum lipo-protein of healthy subjects.The levels of HDL-C、HDL₂-C、HDL₃-C and HDL₂-C/HDL₃-C of the smoking group were obviously lower than those of the non-smoking group, while the levels of LDL-C、VLDL-C and LDL-C/HDL-C of the smoking group were obviously higher than those of the non-smoking group.Moreover, these indices were significantly associated with the smoking amount, smoking duration, depth of inhalation. Smoking was an important dangerous factor for lowering levels of HDL-C, HDL₂-C、HDL₃-C、HDL₂-C/HDL₃-C and raising levels of LDL-C、VLDL-C、LDL-C/HDL-C.The relative risk(RR) of the two factors were estimated to be 1.09~5.77 and 2.37~3.57 respectively.The levels of the 7 indices such as HDL-C of passive smokers were identical with those of light smokers. This showed that passive smoking also had marked influence on cholesterol concentrations in serum lipoprotein.

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