高血压、吸烟、脂代谢紊乱在冠心病中协同作用的研究

何耀; 李良寿; 万志恒; 李兰荪; 贾国良

Abstract

何耀,李良寿,万志恒,李兰荪,贾国良.高血压、吸烟、脂代谢紊乱在冠心病中协同作用的研究[J].Chinese journal of Epidemiology,1992,13(2):101-105

高血压、吸烟、脂代谢紊乱在冠心病中协同作用的研究

Study on the Interaction between Hypertension, Smoking and the Disorder of Lipids Metabolism in the Coronary Artery Disease

Received:March 07, 1990 Revised:June 18, 1990

DOI：

KeyWord: 冠状动脉疾病冠脉造影术危险因素协同作用

English Key Word: Coronary artery disease(CAD) Coronary arteriography Risk Factors Synergy

FundProject:

Author Name	Affiliation
He Yao	Departments of Epidemiology and Cardiology, Fourth Military Medical University, Xian
李良寿	Departments of Epidemiology and Cardiology, Fourth Military Medical University, Xian
万志恒	Departments of Epidemiology and Cardiology, Fourth Military Medical University, Xian
李兰荪	第四军医大学西京医院心脏内科西安市, 710032
贾国良	第四军医大学西京医院心脏内科西安市, 710032

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Abstract:

在100例冠脉造影确诊的冠心病患者和141例非冠心病对照中进行了高血压、吸烟、脂蛋白及载脂蛋白水平与冠状动脉粥样硬化的关系及其三者在冠心病发病中相互作用关系的研究。结果示:(1)高血压水平、累积吸烟量、高密度脂蛋白及其分型和载脂蛋白Al及B的水平与冠状动脉粥样硬化病变程度呈剂量-反应关系;(2)同时具有高血压和吸烟两项危险因素者的冠脉病变程度及脂代谢紊乱较单一因素者更为严重。提示高血压和吸烟之间在冠心病的发生中有某种相互协同作用,推测其机制可能与脂代谢有关。

English Abstract:

The correlations of the coronary artery disease (CAD) and hyperteasion, smoking and/or the levels of lipoproteins and apolipoproteins, were studied in 100 patients with CAD diagnosed by coronary arteriography and 141 non-CAD controls. The findings are:l. There are:significant positive dose-response relationships between the degrees of CAD and the levels of diastolic pressure, cumulative smoking consumptions, the levels of high-density lipoprotein subclasses and apolipoproteins Al and/or B. 2. The degrees of CAD in patients with the hypertension and smoking at same time were more serious than those with only a single risk factor.It's suggested that there are some synergy between hypertension and smoking in the occurrence of CAD. The synergic mechanism may be related to lipids metabolism.

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