| 王润田,林三仁,赵金声,雷道年,李东琛,石中碌,张洁萍,方积乾.胃癌亚类危险因子的流行病学研究——多组Logistic回归分析[J].Chinese journal of Epidemiology,1993,14(5):295-299 |
| 胃癌亚类危险因子的流行病学研究——多组Logistic回归分析 |
| The Epidemiological Study of Subtype Risk Factors of Gastric Cancer |
| Received:March 20, 1992 Revised:July 23, 1992 |
| DOI： |
| KeyWord: 胃肿瘤 危险因素 |
| English Key Word: Stomach neoplasms Rick factors |
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| Abstract: |
| 根据胃癌发生多阶段模式的认识,我们设计实施了一种新的病例对照研究,分析方法采用多组Logistic分析法,研究对象为四组病例和一组对照,他们分别是胃癌组、重度异型增生组、慢性萎缩性胃炎伴肠化生组和溃疡病组以及对照组。对照组是病理证实胃粘膜正常或仅有轻度性慢浅表性胃炎患者。研究结果显示:胃癌的危险因素是长期居住在高发区,经济收入低下,动物蛋白摄入量少,地瓜、墨鱼摄入量大,暴饮暴食和精神创伤。重度异型增生的危险因素是青少年时期蛋白质摄入少,墨鱼、不新鲜鱼、腌肉摄入量大和胃癌阳性家族史。本结果概括和检验了胃癌发生的营养失平衡及亚硝胺和遗传病因假说。 |
| English Abstract: |
| On the basis of understanding multistage pattern of the development of gastric cancer, we designed and carried out a new case-control study. The methods of analysis was multigroup logistic regression analysis. The studied objects were 4 groups of cases and 1 group of control. They were gastric Cancer group, severe dysplasia group, chronic atrophic gastritis accompanied by intestinal metaplasia group, ulcer group and control group, respectively. The control group was confirmed by pathology which showed that the gastric mucosa was normal or had sonly mild chronic superficial gastritis. The renlts showed that the risk factors of gastric cancer were living in high incidence area for a long period, low economic income, low animal protein intake, high sweet potato and inkfish ointake, ating and drinking too much at ne meal and mental injuring The risk factors of severe dysplasia were low intake of protein, intake of non-fresh fish, large intake of inkfish and salted meat, a family history of gastric cancer. |
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