| 杨金升,吴志英,罗晓红.帕金森氏病病因危险因素的病例对照研究[J].Chinese journal of Epidemiology,1994,15(1):6-9 |
| 帕金森氏病病因危险因素的病例对照研究 |
| A Case-Control Study on Risk Factors in Etiology of Parkinson's Disease |
| Received:July 21, 1993 Revised:September 20, 1993 |
| DOI： |
| KeyWord: 帕金森氏病 病例对照 危险因素 |
| English Key Word: Parkinson's disease Case-control study Risk factor |
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| Abstract: |
| 对90例帕金森氏病(PD)病人进行了1:1的病例对照研究,结果表明PD病人有较高的家族史暴露率,提示该病有"遗传易感性"存在。环境危险因素有头部外伤、风湿热病史、抽搐、抗精神药物服用史及毒物接触史,但每一因素均不能解释所有病例。作者认为遗传缺陷时表现的"易感性"与"环境理论"中的多种外源性致病因子的联合作用可以很好的解释PD的发病过程,今后在PD遗传基因定位方面与环境因子的联合研究对揭示PD病因有重要价值。 |
| English Abstract: |
| Risk factors of Parkinson's disease (PD) were studied by the case-control method (1:1) in 90 cases. It was suggested that the high positive rate (34.4%) in PD family history was related to "genetic susceptibility". There was history of head injury, rheumatic fever, seizure, taking anti-psychosis drug or contact with toxins, but any one factor could not completely explain the etiology of PD. We believe that coordinating effects of both susceptibility in genetics and evironmental toxins may explain the mechanism of PD. |
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