| 郑企静,李泉根,龚明敏,刘玉华,李佳,朱虹,阎田玉,赵高潮,庞淑兰,富长伶.1976~1990年北京地区腺病毒肺炎的流行特点及分子流行病学研究[J].Chinese journal of Epidemiology,1994,15(1):14-18 |
| 1976~1990年北京地区腺病毒肺炎的流行特点及分子流行病学研究 |
| Epidemiolog of Adenovirus Pneumonia in Beijing, 1976~1990 |
| Received:March 13, 1993 Revised:October 10, 1993 |
| DOI： |
| KeyWord: 肺炎，腺病毒 基因型 分子流行病学 |
| English Key Word: Adenovirus pneumonia Genome type Molecular epidemiology |
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| Abstract: |
| 对1976~1990年度15个冬春2757例住院肺炎患儿作了病毒学检查,并对80~90年代及部分50、60年代分离的3、7型腺病毒(Ad3、Ad7)99株用12种DNA限制性内切酶作了基因组型分析。研究结果阐明了北京地区腺病毒(Adv)肺炎的流行特点。1976年以来北京地区没有出现Adv肺炎的爆发流行,仅有小规模的流行。Ad3、Ad7仍是Adv肺炎的主要病原,但在不同阶段以一个血清型为主。1982年以后Adv肺炎的发病率逐渐下降,病情减轻。DNA限制性内切酶分析揭示了北京地区引起肺炎Ad3、Ad7基因组型分布。Ad7中有6个基因组型,Ad3中有3个基因组型。1958、1965年曾出现7a1、7a4、7b及7g,以后未再检出;1962年出现3a2。1980~1990年7d及3a2是优势基因组型。Ad7中除1984年一株7d1外均为7d。1984及1986年分别检出3a4及3a6。 |
| English Abstract: |
| From 1976 to 1990 for 15 consecutive epidemic years, virological examinations were carried out on 2757 hospitalized infants and children infected with pneumonia. Ninety-nine strains of types 8 and 7 adenovirus (Ad3, Ad7) isolated from 50s to 90s were analyzed with 12 DNA restriction endonucleases. Results showed the epidemiologic characteristics of adenovirus (Adv) pneumonia in Beijing. Epidemic occurred yearly, but there was no severe outbreak of Adv pneumonia as in 1958. Ad3 and Ad7 were the main etiologic agents of Adv pneumonia. Ad7 was dominant in 1976~1980; while Ad3 was more prevalent in 1981~1990. DNA restriction endonuclease analysis revealed six genome types of Ad7 and three genotypes of Ad3. 7a1, 7a4, 7b and 7g occurred in 1958, 1965, but disappeared between 1980~1990; 3a2 was first detected in 1962. From 1980 to 1990, 7d and 3a2 were the dominant genome types. Among the Ad7 strains only one strain of 7d1 was identified; all others were 7d. 3a4 and 3a6 first appeared in 1984 and 1986, respectively. The changes of epidemic patterns seemed correlated with the variations of genome types. |
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