| 陈惠峰,郭志宏,张友金,王振海,杨介者,陶志华,顾卯官,曹家穗,吴祖云,王文刚,钱本立,姚军,居全弟,许荣全,周钊民.新生儿乙型肝炎疫苗免疫持久性观察及再免研究[J].Chinese journal of Epidemiology,1994,15(2):76-79 |
| 新生儿乙型肝炎疫苗免疫持久性观察及再免研究 |
| Long-term Efficacy of Hepatitis B Vaccine in Newborn and Revaccination Study |
| Received:August 20, 1993 |
| DOI： |
| KeyWord: 乙型肝炎疫苗 抗－HBs 再免疫 |
| English Key Word: HB vaccine Anti-HBs Revaccination |
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| Abstract: |
| 新生儿经乙型肝炎(乙肝)疫苗10μg 3针全程免疫接种4、5年后,抗-HBs阳性率分别为82.54%和72.03%。其抗-HBs低滴度(≥ 10~99mIU/ml)占44.61%,中等滴度(≥ 100~999mIU/ml)占32.34%,最高值为857mIU/ml.对抗-HBs<10mIU/ml与≥ 10mIU/ml的各组予以乙型肝炎疫苗10μg 1剂再免,再免后1个月抗-HBs大幅度升高,3个月时抗-HBs开始回落,6个月时抗-HBs大幅度下降,至12个月左右时抗-HBs逐趋于再免前的水平。本文提示国产乙型肝炎疫苗具良好的免疫效果,5~7年内不必普遍性再免。对抗-HBs<10mIU/ml的儿童再免后有一定禆益,但持续时间较短. |
| English Abstract: |
Two-hundred and Sixty-nine newborns were followed up for 4 and 5 years after completion of vaccination (10μg×3). The anti-HBs positive rates remained 82.54%and 72.03%, respectively. The low-level titer (≥10~99 mIU/ml) made. up 44.61%, and the medium-level titer (≥100~999mIU/ml) 32.34%. The highest titer was 857 mIU/ml. A 10μg dose of hepatitis B vaccine was given to these chidren. The anti-HBs level went up greatly in the first month after revaccination, but started to drop in the third month, decreased rapidly in the sixth month, and in the twelveth month the level trended to restore the level before revaccination.
This paper indicated that the home-made hepatitis Bvaccine was effective. Revaccination was not necessary within 5~7 years after initial vaccination. Revaccination to children whose anti-HBs level was<10mIU/ml was beneficial but the anti-HBs persistence was short. |
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