| 叶本法,沈靖,徐耀初,钮菊英,陈建国,张宝初,柳标,姜允辉.HBV、HCV感染与HCC发生关系的病因学研究[J].Chinese journal of Epidemiology,1994,15(3):131-134 |
| HBV、HCV感染与HCC发生关系的病因学研究 |
| Etiologic Study on the Relationship between HBV, HCV and HCC |
| Received:February 24, 1993 Revised:April 05, 1993 |
| DOI： |
| KeyWord: HBV HCV HCC |
| English Key Word: HBV HCV HCC |
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| Abstract: |
| 应用启东肝癌高发区的调查资料和血清检验资料,对乙肝病毒(HBV)、丙肝病毒(HCV)感染与原发性肝细胞型肝癌(HCC)的关系进行了病因学研究。结果显示:110例HCC中,HBV、HCV的流行率分别为85.45%和17.27%,显著高于对照的50.45%和4.09%,单因素及多元条件Logis-tic回归分析均显示HBV感染指标HBsAg、Pre-S2蛋白和HCV感染指标抗-HCV为HCC的重要危险因素,OR值分别为10.22、2.96和2.68,饮茶为唯一的保护因素,OR值为0.36。HBV与HCV同时感染引起HCC发生的OR值较高为6.48,HBV、HCV分别感染的OR值相似,分别为3.90和3.89,但由于启东人群HBV的感染率较高,其引起HCC的归因危险度最高,为启东HCC的首要病因,HCV也有相当的病因作用,此外尚有11.82%的病例可能由其它环境或遗传因素引起。 |
| English Abstract: |
| A total of 110 HCC patients were. sampled randomly in 20townships of Qidong county (a higher incidence area of HCC in China) from Mar. to Sept. 1989. Each patient was paired with two healthy persons as control. The results showed that the prevalences of HBV and HCV in 110 patients were 85.45% and 17.27% respectively, and were significantly higher than that in control (50.45% and 4.09%). Using Conditional Logistic Regression Model. we found that the main risk factors of HCC in Qidong were HBsAg and Pre-S2 for HBV and anti-HCV for HCV. The OR value were 10.22, 2.96 and 2.63, respectively. Drinking tea was the only protective factor (OR=0.36). Among 110 HCC patients. 13.64% were positive for both HBV and HCV. The OR value was the highest (6.48). 88.18% patients were either HBV or HCV positive. The OR values were similiar (3.90 and 3.89). It suggests that the most important risk factor of HCC in Qidong was HBV infection because it had a higher prevalence among the population while the HCV infection having an equal OR value was also a risk factor. |
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