| 尤尔科,杨全芝,杨秋玲.脊髓灰质炎中和抗体母婴垂直分布血清流行病学研究[J].Chinese journal of Epidemiology,1994,15(3):158-161 |
| 脊髓灰质炎中和抗体母婴垂直分布血清流行病学研究 |
| A Longitudinal Study on Maternal-fetal Transfer of Antibody against Poliomyelitis |
| Received:April 03, 1993 Revised:July 14, 1993 |
| DOI： |
| KeyWord: 脊髓灰质炎 GMT |
| English Key Word: Poliomyelitis GMT |
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| Abstract: |
| 本文对孕妇血、新生儿脐血和2月龄婴儿血中脊灰三型中和抗体垂直分布情况进行研究。结果表明:孕妇血中脊灰三型抗体阳性率在92.5%以上;GMT在14.58~32.67之间;I、II型阳性率、GMT基本一致,III型较低,新生儿脐血比该孕妇血中GMT低50%左右,2月龄婴儿血脊灰三型抗体阳性率和GMT均低于母血和新生儿脐血中脊灰抗体阳性率和GMT;2月龄婴儿脊灰单型抗体阴转率达64.1%~83.87%,三个型别抗体均阴转者达44.8%,与生母及新生儿脐血中和抗体水平呈明显负相关,表明婴儿出生后至2个月初次免疫前,确实存在着免疫裂隙,建议推行新生儿"0"次接种或孕妇第28周开始服OPV。 |
| English Abstract: |
| A study on antibody distribution and titer against poliovirus in 67 mothers and their 60-day-old new-born babies was carried out in Shiyan, Hubei Province. The positive rates and the geometric mean titers of antibodies against Types I-III poliovirus in mothers were 98.58%, 1:32.67; 95.5%, 1:30.07; 92.5%, 1:14.58, respectively. In their 60-day-old babies, the antibody positive rates and geometric mean titers fell obviously; they were 34.3%, 1:2.45:34.3%, 1:2.22; and 14.9%, 1:1.34, respectively. The authors suggest to immune those neonates (OPV zero), or to immune those mothers beginning from 28 weeks of pregnancy in order to raise the antibody titer and protect their babies during the early days. |
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