新生儿乙肝疫苗第2针接种时间与免疫效果关系研究

陈惠峰; 郭志宏; 顾云忠; 张友金; 陈桂尧; 杨介者; 姜霞玲; 沈月根; 陶志华; 王文刚; 姚军; 钱本立

Abstract

陈惠峰,郭志宏,顾云忠,张友金,陈桂尧,杨介者,姜霞玲,沈月根,陶志华,王文刚,姚军,钱本立.新生儿乙肝疫苗第2针接种时间与免疫效果关系研究[J].Chinese journal of Epidemiology,1994,15(6):349-350

新生儿乙肝疫苗第2针接种时间与免疫效果关系研究

A Study on Relation Between Effect of HB Vaccination and Time of the Second Injection

DOI：

KeyWord: 乙肝疫苗接种时间

English Key Word: Hepatitis B vaccine Protective rate

FundProject:

Author Name	Affiliation
Chen Huifeng	Zhejiang Provincial Hygiene and Epidemic Prevention Station, Hangzhou 310009
Guo Zhihong	Zhejiang Provincial Hygiene and Epidemic Prevention Station, Hangzhou 310009
Gu Yunzhong	嘉兴市郊区卫生防疫站
张友金	平湖市卫生防疫站
陈桂尧	嘉兴市郊区卫生防疫站
杨介者	Zhejiang Provincial Hygiene and Epidemic Prevention Station, Hangzhou 310009
姜霞玲	嘉兴市郊区卫生防疫站
沈月根	嘉兴市郊区卫生防疫站
陶志华	平湖市卫生防疫站
王文刚	Zhejiang Provincial Hygiene and Epidemic Prevention Station, Hangzhou 310009
姚军	Zhejiang Provincial Hygiene and Epidemic Prevention Station, Hangzhou 310009
钱本立	Zhejiang Provincial Hygiene and Epidemic Prevention Station, Hangzhou 310009

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Abstract:

新生儿乙肝疫苗免疫接种首针“0”和第3针“6”保持不变,将第2针分为30、40、50、60天组,于第2针免后和全程免后1个月各采血检测,各组抗—HBs阳转率和滴度均无组间差异。不论HBsAg阴性和HBsAg阳性母亲组的新生儿抗—HBs消长变化均与0、1、6程序结果相似。提示对山区、海岛等受客观条件影响大的地区,新生儿乙肝疫苗第2针接种时间可在30~60天完成。

English Abstract:

Three kinds of hepatitis B vaccination schedule in neonates were compared. The schedule included 0, 40 day, 6 month; 0, 50 day, 6 month; 0, 60 day. 6 month; and was controlled by the 0, 30 day, 6 month schedule. The results showed that there was no statistically significant difference among three kinds of schedule, no matter who were neonates of HBs Ag-positive mother or neonates of HBsAg-negative mother. These indicated that in areas with poor condition, such as mountain, island, the second injection of hepatitis B vaccine in neonates may be completed within 30-60 days.

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