不同剂量狂犬疫苗免疫后血清学效果观察

陈爱贞; 孔繁钧; 梅重卿; 钟凌峭; 石亦人

Abstract

陈爱贞,孔繁钧,梅重卿,钟凌峭,石亦人.不同剂量狂犬疫苗免疫后血清学效果观察[J].Chinese journal of Epidemiology,1996,17(3):139-140

不同剂量狂犬疫苗免疫后血清学效果观察

Serological Effect After Immunization with Rabies Vaccine of Different Doses

Received:September 15, 1995 Revised:October 27, 1995

DOI：

KeyWord: 狂犬疫苗血清抗体水平

English Key Word: Rabies vaccine Antibody level

FundProject:

Author Name	Affiliation
Chen Ai-zhen	Foshan Municipal Health and Epidemic Prevention Station, Foshan 528000
Kong Fan-jun	Foshan Municipal Health and Epidemic Prevention Station, Foshan 528000
Mei Zhong-qing	Foshan Municipal Health and Epidemic Prevention Station, Foshan 528000
钟凌峭	Foshan Municipal Health and Epidemic Prevention Station, Foshan 528000
石亦人	Foshan Municipal Health and Epidemic Prevention Station, Foshan 528000

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Abstract:

将91例被犬、猫等动物抓、咬伤者随机分为两组,用不同剂量的狂犬疫苗进行免疫,并应用IFA法检测其免后血清中的抗狂犬病毒抗体水平。结果,实验组(加大剂量组,总量14ml)的抗体应答较对照组(常规5针组,总量10ml)为优。应用IFA和ELISA两种方法对51份标本进行了抗体水平测定的比较,结果显示IFA法略优于ELISA法,两法检出的阳性率分别为72.5%和64.9%。

English Abstract:

Ninety-one cases bitten by pets as dogs, cats were randomly divided into two groups,and immunized with different doses of rabies vaccine. The antibody levels were detected by IFAT after immunization. Result showed that the immune response of the group who recieved boosting doses was better than the 5-doses group. 51 cases were examined by IFAT and ELISA. The positive rates of IFAT and ELISA were 72.5% and 64, 9%,respectively(P<0.05).

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