我国四个地区肝炎病毒感染与肝癌的病例对照研究

俞顺章; 资晓林; 陈刚; 李迥

Abstract

俞顺章,资晓林,陈刚,李迥.我国四个地区肝炎病毒感染与肝癌的病例对照研究[J].Chinese journal of Epidemiology,1997,18(4):214-216

我国四个地区肝炎病毒感染与肝癌的病例对照研究

The Relationship between Viral Hepatitis and Primary Liver Cancer in Four Areas of China

Received:February 24, 1997 Revised:April 01, 1997

DOI：

KeyWord: 乙型肝炎丙型肝炎庚型肝炎肝癌

English Key Word: Hepatitis B Hepatitis C Hepatitis G PLC

FundProject:

Author Name	Affiliation
Yu Shun-zhang	Insitute of Preventive Medicine, Shanghai Medical University, Shanghai 200032
Zi Xiao-lin	Insitute of Preventive Medicine, Shanghai Medical University, Shanghai 200032
Chen Gang	Insitute of Preventive Medicine, Shanghai Medical University, Shanghai 200032
李迥	Insitute of Preventive Medicine, Shanghai Medical University, Shanghai 200032

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Abstract:

为研究乙型、丙型和庚型肝炎与原发性肝癌的关系，对我国江苏海门、福建同安、广西扶绥和河北石家庄四地，进行了以人群或医院为基础的肝癌病例对照研究。在四个地区病例与对照中，HBsAg阳性率分别为66.3%（238/359）和23.4%（84/359），其OR值为6.60；抗-HCV阳性率分别为17.9%（61/340）和6.5%（22/340），OR=3.31；合并乙丙型肝炎感染其肝癌危险度大大增加（OR=110.08）。另对海门病例对照各50例进行HGV-RNA检测，阳性率分别为22%和10%。结果说明：在我国乙型肝炎感染与肝癌关系更为密切。

English Abstract:

To investigate the relationship between hepatitis B,C and G and primary liver cancer (PLC),both population based and hospital based case control studies were conducted in four areas of China. The prevalence rates of HBsAg in 359 pairs of PLC cases and controls were 66.3% and 23.4% (OR=6.60,PAR=55.5%),respectively;the prevalence of anti HCV in 340 pairs of PLC cases and controls were 17.9% and 6.5% (OR=3.31, PAR=12.4%),respectively.When both markers were positive, the OR was higher than their multiple effect of HBsAg and anti HCV.In the Haimen Case control study,serum HGV RNA was detected in 11 of the 50 PLC cases,compared to 5 of the 50 controls matched with age and sex (P > 0.05).These data suggested that HBV might have played a more important role than HCV and HGV in the development of PLC in China.

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