| 谈永飞,姚才良,沈靖,邵亚农,周炎,钮菊英,邵建伟,周家仪,蒋晓东,徐国千,王心如,徐希平.血清脂蛋白(a)与缺血性脑卒中[J].Chinese journal of Epidemiology,1998,19(1):36-38 |
| 血清脂蛋白(a)与缺血性脑卒中 |
| A Study on the Relationship between Lp(a)and Arteriosclerotic Cerebral Infarction |
| Received:June 10, 1997 |
| DOI： |
| KeyWord: 脂蛋白(a) 缺血性脑卒中 病例对照研究 |
| English Key Word: Lp(a) Arteriosclerotic cerebral infarction Case control study |
| FundProject: |
| Author Name | Affiliation | | Tan Yongfei | Department of Rehabilitation, Yixing People's Hospital, Yixing 214200 | | Yao Chailiang | 南京医科大学公共卫生学院 | | Shen Jing | 南京医科大学公共卫生学院 | | 邵亚农 | Department of Rehabilitation, Yixing People's Hospital, Yixing 214200 | | 周炎 | Department of Rehabilitation, Yixing People's Hospital, Yixing 214200 | | 钮菊英 | 南京医科大学公共卫生学院 | | 邵建伟 | Department of Rehabilitation, Yixing People's Hospital, Yixing 214200 | | 周家仪 | 南京医科大学公共卫生学院 | | 蒋晓东 | Department of Rehabilitation, Yixing People's Hospital, Yixing 214200 | | 徐国千 | 南京医科大学公共卫生学院 | | 王心如 | 南京医科大学公共卫生学院 | | 徐希平 | 美国哈佛大学公共卫生学院医学 |
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| Abstract: |
| 采用1∶1 配比病例对照研究方法, 对105 对缺血性脑卒中病人和非脑卒中的对照组病人, 进行了血清脂蛋白(a)、总胆固醇、甘油三脂、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇的检测和分析, 以评价它们与缺血性脑卒中的关系。结果显示:病例组血清脂蛋白(a)平均值为238.37mg/ L, 明显高于对照组的149.98mg/ L, t =3.97, P <0.001, 不同年龄组的比较中, 只有70岁以上年龄组血清脂蛋白(a)明显高于50 岁以下年龄组, 而性别在病例组内或对照组内均无显著性差异, 将血清脂蛋白(a)按不同等级进行分析, 发现随着血清脂蛋白(a)水平升高, 缺血性脑卒中的危险性逐渐增加, 有明显的剂量效应关系, 多因素logistic 回归分析表明, 血清脂蛋白(a)为缺血性脑卒中的独立危险因素, OR =1.93, 其他危险因素还包括甘油三脂, 而高密度脂蛋白胆固醇是缺血性脑卒中的保护因素, OR =0.32。 |
| English Abstract: |
| Using a 1∶1 matched case control study, we analysed the data of 105 arteriosclerotic cerebral infarction cases and controls to detect the levels of TC, TG, HDL-C, LDL-C and Lp(a).The results showed that the average level of Lp(a)in cases was (238.38mg/ L), significantly higher than that of controls (149.98mg/ L t =3.96, P <0.001).Comparing the levels of different age g roups and sex, no sig nificant difference,except the group over 70 years, which was higher than that in other groups was found.Dose-response analy sis also showed that the OR value was positively correlated with the Lp(a).Multi-variable logistic regression model indicated that Lp(a)was an independent risk factor with OR =1.93.Another risk factor was TG.However, LDL-C.HDL-C were found to be the protective factors of arteriosclerotic cerebral infarction, with an OR =0.32. |
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