| 陈宪锐,玄梅香,尹燕明,周玉霞,魏佑农,赵新平,付春生.山东省丁型肝炎病毒感染调查研究[J].Chinese journal of Epidemiology,1998,19(3):138-140 |
| 山东省丁型肝炎病毒感染调查研究 |
| Study of HDV Infection in Shandong Province (1994-1997) |
| Received:October 31, 1997 |
| DOI： |
| KeyWord: 丁型肝炎病毒 丁型肝炎病毒抗体 乙型肝炎病毒 乙型肝炎表面抗原 |
| English Key Word: HDV Anti-HDV HBV Hepatitis B surface antigen |
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| Abstract: |
| 为了解山东省丁型肝炎病毒感染状况，并探讨丁型肝炎病毒(HDV)感染与乙型肝炎病毒(HBV)感染的关系，应用酶联免疫吸附试验(ELISA)对山东省2 681例乙型肝炎病毒感染者进行了血清丁型肝炎病毒抗体(抗-HDV)检测，共检出抗-HDV阳性者207例，阳性率7.72%。HBsAg携带者组抗-HDV阳性率3.16%，乙肝患者组抗-HDV阳性率13.15%，两组之间的差异有非常显著性(P<0.001)。在乙肝患者组中，慢性活动性肝炎患者和重症肝炎患者抗-HDV阳性率高于急性肝炎患者和慢性迁延性肝炎患者，差异有非常显著性(P<0.001)，表明乙肝病史越长、病情越重，其抗-HDV阳性率越高。提示乙肝患者联合或重叠感染HDV与乙肝慢性化和病情加重的形成有关。 |
| English Abstract: |
| To understand the situation of HDV infection in Shandong province and to explore the relationship between HDV and HBV infections,2681 samples infected with HBV were tested for serum anti-HDV with enzyme linked immunosorbent assay,in Shandong.Among them,207(7.72%) were found to be anti-HDV positive.Anti-HDV positive rates in HBsAg carriers and in hepatitis B patients were 3.16% and 13.15%,respectively.A significant difference (P<0.001) was noticed between the two groups.In the second group,anti-HDV positive rates in patients with chronic active hepatitis and severe hepatitis were both higher than those in patients with acute hepatitis and chronic persistent hepatitis and the difference was significant (P<0.001).The longer the history and the more severe the condition the higher of the anti-HDV positive rate was seen.The results indicated that the combined and over-lapping HDV infections were both responsible for the chronic status of hepatitis B and its deterioration. |
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