Abstract
倪进发,阚晓宏,毕鹏,孙业桓,章秋霞,张庶民,程慧,黄守凯.丙型肝炎病毒感染后慢性转化率的流行病学研究[J].Chinese journal of Epidemiology,1998,19(3):144-146
丙型肝炎病毒感染后慢性转化率的流行病学研究
An Epidemiological Study on the Rate of Becoming Chronic in HCV Infection
Received:October 31, 1997  Revised:December 10, 1997
DOI:
KeyWord: 丙型肝炎  慢性转化率
English Key Word: Hepatitis C  Chronic rate
FundProject:安徽省自然科学基金
Author NameAffiliation
Ni Jinfa Department of Epidemiology, Anhui Medical University, Hefei 230032 
Kan Xiaohong Department of Epidemiology, Anhui Medical University, Hefei 230032 
Bi Peng Department of Epidemiology, Anhui Medical University, Hefei 230032 
Sun Yeheng Department of Epidemiology, Anhui Medical University, Hefei 230032 
Zhang Qiuxia 安徽省立医院传染科 
Zhang Shumin 中国药品生物制品检定所疫苗二室 
Cheng Hui Department of Epidemiology, Anhui Medical University, Hefei 230032 
Huang Shoukai Department of Epidemiology, Anhui Medical University, Hefei 230032 
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Abstract:
      笔者选择1992~1996年间,安徽某乡“职业”供血员和2所省级医院住院病人中,抗-HCV(+)和/或HCV RNA(+)者为调查对象。追访了他们HCV感染及其后的有关重要临床诊治和流行病学信息,同时调查了感染者的现况及相关实验室指标检测,描述了供血员人群丙型肝炎病毒感染后慢性转化率变化趋势。结果HCV感染6个月后慢性转化率为55.93%,1~4年慢性转化率依次为50%、48.54%、46.47%和46.43%。表明其感染后慢性转化率一直持续高水平,下降缓慢,尤其2年后基本稳定在46%~48%,远高于乙型肝炎5%~10%的慢性转化率。
English Abstract:
      Anti-HCV(+) and/or HCV RNA(+) were chosen for study on patients admitted to two provincial hospitals and “professional” blood donors in one of the areas in Anhui province in 1992-1996.Clinical diagnosis,treatment and epidemiology on HCV infection were retrospectively reviewed and in the meantime their present condition together with experimental data were studied;Chronic tendency on HCV infection of blood donors was described.Results showed that the rates of duration on becoming chronic for HCV infection were:six month later-55.93%,one year-50%,two-years-48.54%,three years-46.47% and four years-46.43%.Rate of becoming chronic after HCV infection was continuously in high level,then slowly decreasing, to 46%-48% in two years,still much higher than hepatitis B which had a rate of 5%-10% becoming chronic.
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