| 严延生,郑兆双,邵一鸣,陈舸,颜苹苹,苏玲,郑健.福建省艾滋病流行特征及流行趋势分析[J].Chinese journal of Epidemiology,1999,20(1):23-26 |
| 福建省艾滋病流行特征及流行趋势分析 |
| Analysis on the epidemic characterization and trend of AIDS in Fujian Province |
| Received:June 12, 1998 Revised:September 14, 1998 |
| DOI： |
| KeyWord: 艾滋病 流行病学监测 人免疫缺陷病毒Ⅰ型 |
| English Key Word: AIDS Epidemiological surveillance HIV-1 |
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| Abstract: |
| 目的 分析实验室及流行病学调查等资料，认识艾滋病在福建省的流行特征及推测其流行趋势，为制定福建省艾滋病防治策略提供科学依据。方法 使用酶联免疫吸附法（ Ｅ Ｌ Ｉ Ｓ Ａ）及免疫印迹试验对高危及特定人群标本进行人免疫缺陷病毒（ Ｈ Ｉ Ｖ） 抗体检测，对抗体阳性者进行个案流行病学调查及收集艾滋病病人临床资料，采集感染者全血分离淋巴细胞用套式聚合酶链反应扩增 Ｈ Ｉ Ｖ-１ Ｄ Ｎ Ａ 片段进行序列分析鉴定病毒亚型。结果 从１９８７ 年１ 月至１９９７ 年１２ 月３０日止，全省共检测了５６９８７０ 份标本，检出 Ｈ Ｉ Ｖ 抗体阳性７０ 例，检出率为０.１２‰。其中 Ａ Ｉ Ｄ Ｓ 病人２１例，已死亡１８ 例。福建省 ＨＩＶ／ ＡＩＤＳ 病例主要分布在福州、泉州和厦门等经济较发达的沿海地区，以境外感染为主，并向国内蔓延扩散，经异性性接触感染是福建省抗体阳性者的主要感染途径。１７例艾滋病病人临床资料分析表明，艾滋病人存活期短,早期症状以持续或反复发热为主，艾滋病病毒序列分析证实 ＨＩＶ－１ Ｅ 亚型为福建省主要流行株。结论 福建省艾滋病将主要在性乱人群中流行 |
| English Abstract: |
| Objective To analysed the epidemic char acterization and trend of AIDS in Fujian Province based on data obtained from HIV sero-surv allance, HIV-1 subtyping and epidemiological survey.Methods Serum samples collected from people in high risk groups and specific subgroups were examined for antibody against human immunodeficiency virus (HIV). Epidemiological investigation was conducted toward people who were sero-positive. Clinical data on patients with AIDS were also collected. Peripheral blood mononuclear cells(PBMCs) obtained from HIV-1 infectious and patients with AIDS were used for DNA amplification between C2-V3 region by PCR. The amplified products were sequenced to identify HIV-1 subtypes.Results From January 1987 through the end of December 1997, a tot al number of 569873 serum samples from high risk groups and specific subgroups including blood do nors and people that travelling abroad frequently were examined for HIV antibody. Seventy people with HIV-1 sero-positive were identified, accounting for 0.12‰ of the total detected numbers. Among them, 21 patients with AIDS in which 18 cases had died. HIV/ AIDS cases were mainly distributed along the coastal cities as Fuzhou, Quanzhou and Xiamen where economic development was g rowing rapidly. Most cases were infected abroad and spreading HIV to the country through sexual transmission. Clinical data showed that early syndromes and reversal fever of patients with AIDS were seen but survival time was short. Nucleotide sequencing showed that HIV-1 strains in the province were most subtype E.Conclusion HIV epidemic in the province will mainly be spreading among people with sexually promiscuous behaviors. |
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