肺炎支原体下呼吸道感染患儿血清肿瘤坏死因子-α、白细胞介素-8的检测

车莉; 卢竞; 鲁杰; 赵小元; 刘小燕

Abstract

车莉,卢竞,鲁杰,赵小元,刘小燕.肺炎支原体下呼吸道感染患儿血清肿瘤坏死因子-α、白细胞介素-8的检测[J].Chinese journal of Epidemiology,1999,20(1):50-52

肺炎支原体下呼吸道感染患儿血清肿瘤坏死因子-α、白细胞介素-8的检测

Measurement of serum tumor necrosis factor-αand interleukin-8 in children with low respiratorytract infection (LRTI) caused by Mycoplasma pneumonia

Received:September 29, 1998 Revised:October 27, 1998

DOI：

KeyWord: 支原体.肺炎肿瘤坏死因子白细胞介素-8

English Key Word: Mycoplasa pneumonia Tumor necrosis factor Interleukin-8

FundProject:

Author Name	Affiliation
CHE Li	Capital Institute of Pediatrics, Beijing 100020
LU Jing	Capital Institute of Pediatrics, Beijing 100020
LU Jie	Capital Institute of Pediatrics, Beijing 100020
赵小元	Capital Institute of Pediatrics, Beijing 100020
刘小燕	Capital Institute of Pediatrics, Beijing 100020

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Abstract:

目的　探索肺炎支原体所致下呼吸道感染的免疫学发病机制。方法　采用顺序饱和液相竞争放射免疫分析法及夹心酶免疫放射分析法对３０例肺炎支原体所致下呼吸道感染患儿血清进行了肿瘤坏死因子（ＴＮＦ）-α和白细胞介素-８（ＩＬ-８）的检测。结果　肺炎支原体所致下呼吸道感染患儿血清中ＴＮＦ-α及ＩＬ-８水平均明显高于健康儿童；ＴＮＦ-α和ＩＬ-８升高呈正相关。结论ＴＮＦ-α在肺炎支原体所致下呼吸道感染中起着重要作用，也是ＩＬ-８升高的重要促进因子。

English Abstract:

Objective To investigate the immunopathological mechanism of LRTI caused by Mycoplasma pneumonia.Methods Serum tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) from 30 patients with LRTI caused by Mycoplasma pneumonia, were measured with sequence saturated solution competitive radioimmunoassay and sandwich ELISA.Results The level of serum TNF-α and IL-8 of patients suffering from LRTI caused by Mycoplasma pneumonia were magnificently higher than that of healthy children. Meanwhile, a positive relationship between serum TNF-α and IL-8 was noticed.Conclusion　TNF-αplays an important role in LRTI caused by Mycoplasma pneumonia, and serves the key factor to the elevation of IL-8.

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