乙型和丙型肝炎病毒重叠感染的研究

陈宪锐; 玄梅香; 吴多文; 尹燕明; 张玉江; 周玉霞; 魏佑农; 付春生

Abstract

陈宪锐,玄梅香,吴多文,尹燕明,张玉江,周玉霞,魏佑农,付春生.乙型和丙型肝炎病毒重叠感染的研究[J].Chinese journal of Epidemiology,1999,20(3):141-143

乙型和丙型肝炎病毒重叠感染的研究

Study of superinf ection of HBV and HCV

Received:November 10, 1998 Revised:January 04, 1999

DOI：

KeyWord: 乙型肝炎病毒丙型肝炎病毒丙型肝炎病毒抗体

English Key Word: HBV HCV A nti-HCV

FundProject:

Author Name	Affiliation
CHEN Xianrui	Taishan Medical College, Shandong Province 271000
XUAN Meixiang	山东省泰安市卫生防疫站
WU Duowen	Taishan Medical College, Shandong Province 271000
尹燕明	Taishan Medical College, Shandong Province 271000
张玉江	Taishan Medical College, Shandong Province 271000
周玉霞	Taishan Medical College, Shandong Province 271000
魏佑农	山东新汶矿务局中心医院
付春生	山东聊城地区人民医院

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Abstract:

目的为了解乙型肝炎患者重叠感染丙型肝炎病毒(HCV)的状况,并探讨乙型肝炎病毒(HBV)、HCV重叠感染时HCV对HBV复制的影响。方法应用ELISA法对712例乙型肝炎患者进行了血清抗-HCV检测和乙型肝炎病毒标志检测。结果712例乙型肝炎患者血清抗-HCV阳性率为14.47%,其中重型肝炎患者血清抗-HCV阳性率最高(48.98%),急性肝炎患者最低(3.25%)。在不同临床类型的乙型肝炎患者之间,血清抗-HCV阳性率存在显著性差异(P<0.001),显示病情越重,病程越长,血清抗-HCV阳性率越高;在HBV和HCV重叠感染的患者中,血清HBsAg、HBeAg和抗-HBcIgM阳性率低于乙型肝炎患者(P<0.001,P<0.001和P<0.05),而血清抗-HBe阳性率高于乙型肝炎患者(P<0.01),均有显著的统计学意义。结论乙型肝炎患者重叠感染HCV与病情加重和慢性化的形成有关,并使HBV的复制受到抑制。

English Abstract:

Objectives T o understand the situation in hepatitis B pat ients coinciding w ith HCV and to ex plor e its influence on HCV on the replication of HBV . Methods U sing ELI SA, 712 hepatit is B patients w er e tested for serum anti-HCV and mar kers of HBV. Results Of the 712 patients, anti-HCV posit ive rate w as 14. 47% w ith the hig hest 48. 98% in patients wit h severe hepatitis and the lowest 3. 25% in patients w ith acute hepatitis. M arkedly different anti-HCV positiv e rates ( P <0. 001) in patients of different clinical stag es w ere discover ed. The more severe the case with long er the course, the higher the ant i-HCV positive rates. In patients w ith superinfection of HBV and HCV,serum HBsAg, HBeA g and anti-HBcIgM positive rates were lower than those in patients w ith hepatitisB ( P < 0. 001, P < 0. 001 and P < 0. 05) but the anti -HBe positive rates w er e higher . All the differ ences show ed an obvious statistical significance. Conclusion Hepatitis B coinciding w ith HCV infectio n is r esponsible for the deter ioration of the disease and towards its fo rmat ion of its chronic phase as w ell as for the inhibition of HBV replication.

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