微量元素与直肠癌关系的分析及意义

韩存芝; 梁小波; 荆洁线; 江波; 赵先文; 郭晋纲; 李跃平; 白文启

Abstract

韩存芝,梁小波,荆洁线,江波,赵先文,郭晋纲,李跃平,白文启.微量元素与直肠癌关系的分析及意义[J].Chinese journal of Epidemiology,1999,20(3):166-169

微量元素与直肠癌关系的分析及意义

Study on the association and significance between trace elements and rectal cancer

Received:March 16, 1999 Revised:March 22, 1999

DOI：

KeyWord: 直肠癌微量元素

English Key Word: Rectal cancer Trace element

FundProject:

Author Name	Affiliation
HAN Cunzhi	Dept. of Aetiology, Shanxi Cancer Institute, Taiyuan 030013
LIANG Xiaobo	山西省肿瘤医院肛肠外科
JING Jiexian	Dept. of Aetiology, Shanxi Cancer Institute, Taiyuan 030013
江波	山西省肿瘤医院肛肠外科
赵先文	Dept. of Aetiology, Shanxi Cancer Institute, Taiyuan 030013
郭晋纲	Dept. of Aetiology, Shanxi Cancer Institute, Taiyuan 030013
李跃平	山西省肿瘤医院肛肠外科
白文启	山西省肿瘤医院肛肠外科

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Abstract:

目的探讨部分微量元素与直肠癌发病的关系。方法采用原子吸收分光光度计对60例直肠癌患者的癌组织,非病变组织及血清中铜、锌、铁、锰、钙、铬、镉水平及铜/锌比值进行测定,采用t检验和非条件logistic回归多因素分析方法对测定结果进行分析。结果直肠癌患者血清、癌组织中铜、镉水平和铜/锌比值与健康对照组和非病变组织比较明显高;而锌、锰、钙、铬水平则明显低,均差异有显著性(P<0.05、P<0.001)。蕈伞型癌组织中铜水平和铜/锌比值高于溃疡型,而锌低于溃疡型,差异有显著性(均P<0.01)。在癌组织和非病变组织中最终进入方程的元素有锌,与直肠癌的相对危险度(OR)为0.3051,95%可信限CI为0.1549~0.6011。在癌患者和健康人血清的比较中,最终进入方程的元素有铜、锌、锰和钙,与直肠癌OR值(95%CI)分别为29.44(4.1748~207.6228)、0.0960(0.0162~0.5679)、0.0426(0.0028~59.7126)、0.9646(0.9354~0.9947),经X²检验均差异有显著性(P<0.05、P<0.001)。结论结果提示锌、锰、钙可能是直肠癌保护因素,而铜为危险因素。

English Abstract:

Objective To study the association between the levels of trace elements and cause of rectal cancer. Methods Cancer tissue, normal tissue, serum levels of Zinc、Copper 、Iron、M anganese、Calcium、Chr omium and Cadmium and Cu/ Zn ratio were determined by atomic absor ption spectrophotometry in 60 pat ients w ith r ectal cancer and in 60 healthy subjects. Results The results of single-variabe analysis showed in serum and malig nant tissue of patients with rectal cancer of Copper、Cadmium levels and Cu/ Zn ratio were sig nificantly higher and Zinc、M anganese、Calcium、Chromium were significantly lower than normal tissue and serum of healthy subjects ( P < 0. 05、P < 0. 001) . The results also showed that Copper level and Cu/ Zn ratio were significantly higher and Zinc level was significantly lower in fung at ing form than ulceration for m cancer tissue( both P v alues < 0. 01) . Multivar iable logistic regression analysis showed that the Odd Ratio ( OR) and 95% Confidence Iimits ( CI) of Copper、Zinc、M anganese and Calcium in serum were 29. 44( 4. 1748-207. 6228) 、0. 0960( 0. 0162-0. 5679) 、0. 0426 ( 0. 0028 -59. 7126 ) and 0. 9646 ( 0. 9354 -0. 9947) r espectiv ely. The OR and 95% CI of Zinc in tissue were 0. 3051 and 0. 1549-0. 6211 respectively. Conclusions Our results indicated that Copper mig ht serve as a risk factor while Zinc、Calcium and M ang anese w ere protective factors to the cause of rectal cancer.

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