| 徐爱强,宋立志,王常银,王爱莲,许青,肖作奎,王少华,李漫时,郝淑珍,李震.婴幼儿接种国产BRDⅡ株风疹疫苗后免疫持久性观察[J].Chinese journal of Epidemiology,2000,21(2):117-120 |
| 婴幼儿接种国产BRDⅡ株风疹疫苗后免疫持久性观察 |
| An observation of the immuno-persistence after inoculating with the domestic BRD Ⅱ strain rubella vaccine among infants and young children |
| Received:October 28, 1999 |
| DOI： |
| KeyWord: 风疹疫苗 免疫持久性 血凝抑制抗体 |
| English Key Word: Rubella vaccine Immuno-persistence Hemagglutination inhibition antibody |
| FundProject: |
| Author Name | Affiliation | | XU Aiqiang | Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014, China | | SONG Lizhi | Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014, China | | WANG Changyin | Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014, China | | 王爱莲 | Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014, China | | 许青 | Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014, China | | 肖作奎 | Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014, China | | 王少华 | Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014, China | | 李漫时 | Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014, China | | 郝淑珍 | Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014, China | | 李震 | Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014, China |
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| Abstract: |
| 目的 研究婴幼儿接种国产BRDⅡ株风疹减毒活疫苗后的免疫持久性. 方法 以血凝抑制 (HI)抗体方法, 选择城区既往无风疹感染和风疹疫苗免疫史的 6～ 18月龄组婴幼儿, 对其接种风疹疫苗 1年和 2年后的抗体水平进行检测. 结果 在6、7、8、9、12和18月龄组初免获得成功的儿童中, 接种风疹疫苗 1年和 2年后, 各组HI抗体阳性率仍分别高达94. 44 %、97. 22%、96. 67%、100. 00%、100. 00%、100. 00%和 93. 10%、93. 55%、96. 77%、96. 97%、100. 00%、100. 00% (P>0. 05), 但免后1年和2年的GMRTs则分别较免后1个月和免后1年约降低了50%, 且免后2年6～7月龄组的GMRTs(29. 89)显著低于8～18月龄组 (53. 00)的结果(t=3. 58, P<0. 001). 结论 国产风疹疫苗起始免疫月龄不宜太小, 以儿童出生后8月龄为宜, 加强免疫的时间可暂时参考国外目前已实行的免疫方案 |
| English Abstract: |
| Objective To study the immuno-persistence after inoculating with the domestic BRDⅡ strain rubella vaccine among infants and young children. Methods Hemagglutination inhibition (HI) antibody detection method was used to test on children at age 6 to 18 months without rubella infection or rubella vaccine immunization in Yantai city of Shandong province and were selected for the observation of the immuno-persistence against the domestic BRD Ⅱ strain rubella vaccine from 1995 to 1998. Results Positive rates of HI antibody among children of 6, 7, 8, 9, 12 and 18 month-old of inoculation were 94. 44%, 97. 22%, 96. 67%, 100. 00%, 100. 00%, 100. 00% and 93. 10%, 93. 55%, 96. 77%, 96. 97%, 100. 00%, 100. 00%(P>0. 05), in one or two years nespectively. The geometric mean reverse titers (GMRTs) were about 50% lower than that after 1 month after 1 year. Similar resutls were found that after 2 years GMRTs was about 50% lower than that after 1 year of inoculation. There was highly significant difference on GMRTs of HI antibody between infants with 6 to 7 month-olds (29. 89)and young children with 8 to 18 month-olds (53. 00) after 2 years of inoculation (t=3. 58, P<0. 001). Conclusion The immunization schedule at the first dose for BRDⅡ strain rubella vaccine should be started when the child is 8 month old. For the second dose, the immunization schedule used in other developed countries should be referred adopted in China. |
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