| 曹卫华,李立明,胡永华,詹思延,李晓晖,李芃,吴涛,李俊,王涛.盐酸苯那普利药物上市后的流行病学监测[J].Chinese journal of Epidemiology,2000,21(3):190-193 |
| 盐酸苯那普利药物上市后的流行病学监测 |
| Evaluation on the effect of Benazepril for hypertension through postmarketing surveillance |
| Received:January 20, 2000 |
| DOI： |
| KeyWord: 高血压 流行病学 盐酸苯那普利 |
| English Key Word: Hy pertension Epidemiolog y Benazepril |
| FundProject:国家“九五”攻关课题（编号：96-906-02-05） |
| Author Name | Affiliation | | CAO Weihua | Department of Epidemiology, Beijing Medical University, Beijing 100083, China | | LI Liming | Department of Epidemiology, Beijing Medical University, Beijing 100083, China | | HU Yonghua | Department of Epidemiology, Beijing Medical University, Beijing 100083, China | | 詹思延 | Department of Epidemiology, Beijing Medical University, Beijing 100083, China | | 李晓晖 | Department of Epidemiology, Beijing Medical University, Beijing 100083, China | | 李芃 | Department of Epidemiology, Beijing Medical University, Beijing 100083, China | | 吴涛 | Department of Epidemiology, Beijing Medical University, Beijing 100083, China | | 李俊 | Department of Epidemiology, Beijing Medical University, Beijing 100083, China | | 王涛 | Department of Epidemiology, Beijing Medical University, Beijing 100083, China |
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| Abstract: |
| 目的 评价盐酸苯那普利药品在以社区为基础的原发性高血压患者人群中使用的降压效果和安全性。方法 连续收集了 1831例服用盐酸苯那普利药的原发性高血压患者的 18个月用药记录，包括血压水平、用药和不良反应情况等。结果 患者人群既往服药患者占1/3，按规定服药和单独服用盐酸苯那普利者占 96%以上。盐酸苯那普利的有效率从 3个月的 73.6%上升到 18个月的84.7%，各种特征的患者均有效。 18个月的血压下降幅度为收缩压/舒张压 1.4/0.9kPa（10.8/6.7mmHg）。 416人出现不良反应，发生率22.7%，主要不良反应类型是咳嗽。首次发生不良反应的高峰出现在治疗的前 3个月内，轻度占近 6 0%。结论 长期服用盐酸苯那普利的降压效果是肯定的，同时又是安全的。 |
| English Abstract: |
| Objective To evaluate the efficacy and safe ty of Benazepril used among the essential hypertensives.Methods 1 831 essential hypertensive patients aged 35 to 75 were randomly selected from acommunity and followed for 18 months.The level of blood pressure, status o f taking Benazepril and side effects w ere sequencially collected.Results 1/3 of the patients had taken antihyper tensive drug befo re the study and the rate of compliance was over 96%.The effective rate of Benazepril was 73.6% at three months and increased to 84.7% at 18 months.Comparing with the baseline da ta, SBP and DBP declined 10.8 mmHg and 6.7 mmHg respectively.The rate of side effect was 22.7%.Cough was most commo nly seen among side effects.The peak of first reco rding on side effect occurred at three months including 60% of them mild.ConclusionResults showed tha t Benazepril had good efficacy and safe ty for the essential hypertension patients in a long-term observation. |
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