蔬菜与云锡矿工肺癌的队列研究

吕全军; 姚树祥; 黄承钰; 兰亚佳; 仓绍义; Phillip R.Taylor; 乔友林; 王瑞淑

Abstract

吕全军,姚树祥,黄承钰,兰亚佳,仓绍义,Phillip R.Taylor,乔友林,王瑞淑.蔬菜与云锡矿工肺癌的队列研究[J].Chinese journal of Epidemiology,2000,21(3):205-207

蔬菜与云锡矿工肺癌的队列研究

A cohort study on the relationship between vegetable intake and risks of lung cancer in the Tin Corporation(YTC)miners in Yunnan

Received:December 08, 1999

DOI：

KeyWord: 肺癌 Cox回归

English Key Word: Lung cancer Cox regression

FundProject:CMB综合发展项目资助课题（编号：96-22-03）

Author Name	Affiliation
LU Quanjun	The Section of Nutrition and Food Hygiene, Department of Public Health, WCUMS, Chengdu 610041, China
YAO Shuxiang	云南锡业公司劳动保护研究所营卫室
HUANG Chengyu	The Section of Nutrition and Food Hygiene, Department of Public Health, WCUMS, Chengdu 610041, China
兰亚佳	The Section of Nutrition and Food Hygiene, Department of Public Health, WCUMS, Chengdu 610041, China
仓绍义	云南锡业公司劳动保护研究所营卫室
Phillip R.Taylor	Cancer Preventio Studies Branch, CPRP, PCPC, NationalCancerInstitute, Bethesda MD 20892, USA(PhillipR. Taylor)
乔友林	中国医学科学院肿瘤医院
王瑞淑	The Section of Nutrition and Food Hygiene, Department of Public Health, WCUMS, Chengdu 610041, China

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Abstract:

目的　为了解蔬菜与云锡（YTC）矿工肺癌危险性的关系。方法　研究食物频率问卷（FFQ）资料中蔬菜摄入频率的重复性和有效性，在此基础上用 χ² 检验、单因素、多因素cox回归分析了云锡矿工肺癌高危人群不同蔬菜摄入频率、总蔬菜摄入量与其发生肺癌相对危险性的关系。结果　冬瓜、黄瓜、菠菜、芹菜、鲜辣椒、鲜黄豆、四季豆、红薯、芦笋、嫩竹笋、青玉米等 11种蔬菜摄入频率的重复性和有效性较好（r=0.2 0~0.33，P<0.0 5）；在这 11种蔬菜中有冬瓜、黄瓜、芹菜、鲜辣椒4种蔬菜在不同摄入频率和总蔬菜不同摄入量时云锡矿工肺癌发病率差异有显著性（χ² =8.83~30.64，P<0.0 5）；与肺癌相对危险性呈负相关（RR<1，P<0.0 5）；经调整年龄、工龄、吸烟后，冬瓜、芹菜 2种蔬菜仍然显示与矿工肺癌危险性呈负相关（P<0.05）。结论　本研究表明蔬菜尤其是芹菜和冬瓜对云锡矿工肺癌确有保护作用，但作用较弱。

English Abstract:

Objective To understand the relationship between vege table intake and risk of lung cancer in the Tin Corpora tio n(YTC)miners in Yunnan.Methods The reproducibility and v alidity of frequency of vegetable intake in Foo d Frequency Questionnaire(FFQ)w ere studied and the co rrelations between different v eg etable intake and frequency and lung cancer relative risk amo ng high risk populatio n of lung cancer by Chi-square, single-and multi-Cox regression w ere analyzed.Results Results show ed that the reproducibility and validity o f wax g ourd, cucumber, spinach, wild celery, fresh bush pepper, fresh soybean, sweet potatoes, asparag us, fresh bamboo shoot were g ood(r =0.20-0.33, P<0.05);There were significantly different incidences o f lung cancer in different frequencies of w ax gourd, cucumber, wild celery, fresh bush pepper out of 11 v ege tables intake, and also in different to tal vegetable intakes(χ² =8.83-30.64, P<0.05).11 vegetables and to tal veg etable intake were significantly negatively co rrelated with risks of lung cancer（RR<1, P<0.05).Only 2 vegetable frequencies were negatively co rrelated with risk of lung cancer by adjusting confounders such as age, occupational histo ry, and smoking(P<0.05).Conclusion　This suggested that vegetables intake may have a role in decreasing the incidence of lung cancer.

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