高长明,李忠佑,丁建华,王建东,胡旭,刘体康,徐天亮,李洪川,Fujiyoshi Toshinobu,Takezaki Toshiro,Tajima Kazuo.人类白细胞抗原DRB1等位基因与幽门螺杆菌感染的关系[J].Chinese journal of Epidemiology,2000,21(6):417-419 |
人类白细胞抗原DRB1等位基因与幽门螺杆菌感染的关系 |
Study on the relations between HLA-DRB1 alleles and Helicobacter pyloriinfection |
Received:June 23, 2000 |
DOI: |
KeyWord: 人类白细胞抗原DRB1等位基因 幽门螺杆菌 胃癌 |
English Key Word: Gene frequency of HLA-DRB1 Helicobacter pylori Gastric cancer |
FundProject: |
Author Name | Affiliation | GAO Changming | Department of Epidemiology, Jiangsu Institute of Cancer Research, Nanjing 210009, China | LI Zhongyou | Department of Epidemiology, Jiangsu Institute of Cancer Research, Nanjing 210009, China | DING Jianhua | Department of Epidemiology, Jiangsu Institute of Cancer Research, Nanjing 210009, China | WANG Jiandong | Department of Epidemiology, Jiangsu Institute of Cancer Research, Nanjing 210009, China | HU Xu | 淮安市卫生防疫站 | LIU Tikang | 邳州市卫生局 | XU Tianliang | 淮安市卫生防疫站 | LI Hongchuang | 日本鹿儿岛大学医学部 | Fujiyoshi Toshinobu | 日本鹿儿岛大学医学部 | Takezaki Toshiro | 日本爱知县癌中心研究所疫学 | Tajima Kazuo | 日本爱知县癌中心研究所疫学 |
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Abstract: |
目的 研究人类白细胞抗原 (HLA)DRB1等位基因与幽门螺杆菌 (Hp)感染的关系。 方法 用BioseedHp IgG定量酶联免疫试剂盒检测 46例胃癌、75例食道癌和100例人群对照的Hp IgG抗体,用Biotest低解析水平HLA DRB酶联免疫探针杂交测定试剂盒检测HLA DRB1等位基因。结果 (1)Hp IgG阳性组DRB108基因频度显著高于Hp IgG阴性组 (13.1%vs 4.4% ;χ2 =11.14,P<0.001)。Hp IgG阳性组DRB1 12基因频度显著低于Hp IgG阴性组 (5.4%vs 11.3 % ;χ2 =4.49,P <0.05 )。(2)胃癌组中DRB1 0 2基因频度显著高于对照组,而DRB107基因频度显著低于对照组,但在胃癌、对照的Hp IgG阳性组和Hp IgG阴性组之间的DRB1 02、DRB107基因频度差异均无显著性。结论 (1)HLA DRB108基因阳性可能增加对Hp的易感性,DRB1 12基因可能是抵御Hp感染的保护性基因。 (2)DRB102基因阳性可能是胃癌的宿主遗传危险因素、DRB107基因可能是胃癌的保护性因素,但DRB102、DRB107基因与胃癌的联系和Hp感染无关 |
English Abstract: |
Objective In order to study the relation between human leukocy te antigen (HLA)DRB1 alleles and Helicobacter py lori (Hp)infection.Methods Hp-I gG antibody from 46 g astric cancer(GC), 75 esophageal cancer and 100 population-based controls w ere identified by Hp-I gG quantitative enzyme immunoassay.Biotest HLA-DRB enzyme linked probe hybridization assay kit (low resolution)w as used to identify DRB1 alleles.Results (1)Frequency of DRB1 *08 was sig nificantly higher in Hp-IgG positive g roup than in Hp-IgG neg ative group (13.1% vs 4.4 %, χ2 =11.14, P <0.001).Frequency of DRB1 *12 w as sig nificantly lower in Hp-IgG positive g roup than in Hp-IgG negatives (5.4 % vs 11.3%,χ2 =4.49, P <0.05).(2)Frequency of DRB1 *02 in GC was significantly higher than that of controls. Frequency of DRB1 *07 in GC was sig nificantly lower than that of controls.However, neither the frequency of DRB1 *02 between Hp-IgG positive and Hp-I gG negative groups nor the frequency of DRB1 *07 betw een Hp-IgG positive and Hp-IgG negative g roups show ed significant differences in GC and controls.Conclusions (1)HLA-DRB1 *08 mig ht serve a gene tic risk factor for Hp infection while DRB1*12 mig ht play a role of pro tecting effect against Hp infection.(2)DRB1 *02 mig ht be a genetic risk factor fo r GC w hile DRB1 *07 might play a role of protecting effect against GC.However, the relations between DRB1 *02, DRB1*07 and GC were not associated with Hp infection. |
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