口服避孕药和基因多态性与不同类型脑卒中关系的初步探讨

陈建锋; 李瑛; 周建伟; 王心如

Abstract

陈建锋,李瑛,周建伟,王心如.口服避孕药和基因多态性与不同类型脑卒中关系的初步探讨[J].Chinese journal of Epidemiology,2001,22(4):273-276

口服避孕药和基因多态性与不同类型脑卒中关系的初步探讨

A study of relationship between oral contraceptives and gene polymorphism and types of stroke

Received:October 10, 2000

DOI：

KeyWord: 口服避孕药脑卒中病例-病例研究基因

English Key Word: Oral contraceptives Stroke Case-case study Gene

FundProject:国家“九五”科技攻关项目 (969040306)

Author Name	Affiliation
Chen Jianfeng	School of Public Health, Nanjing Medical University, Nanjing 210029, China
Li Ying	江苏省计划生育科学技术研究所流行病学研究中心
Zhou Jianwei	School of Public Health, Nanjing Medical University, Nanjing 210029, China
王心如	School of Public Health, Nanjing Medical University, Nanjing 210029, China

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Abstract:

：目的探讨使用复方口服避孕药 (COC)与不同类型脑卒中发生的关系 ,以及遗传易感因素在服药妇女发生脑卒中的过程中作用。方法选取 111例女性脑卒中患者 ,用基因多态性分析法观察凝血因子ⅤLeiden突变 (G16 91→A)、凝血酶原基因多态性 (G2 0 2 10→A)和血管紧张素转化酶(ACE)基因多态性 (I/D)的分布。运用病例病例研究的方法分析危险因素在出血性和缺血性脑卒中之间的差异。结果与未使用COC妇女相比 ,服药妇女发生出血性脑卒中的危险要显著高于缺血性脑卒中 (OR =3.0 3) ;体质指数≥ 2 4kg/m2 与缺血性脑卒中的联系强于出血性脑卒中 (OR =2.99基因多态性分析未能找到C1691→A和C20210→A突变.D型AcE等位基因频率在缺血性脑卒中组中略高.但无显著性结论结果提示烤麸避孕药可能与出血性脑卒中有关.而未见与C 1691→A和C20210→A突变以及ACE基因VD多态性有相关性

English Abstract:

Objective To evaluate the relationship betwecm combined oral contaceptiver(COC) taking and differential types of stroke together with Lhe role of Lhe susceptive genetic factors associatedwith Lhe onset of stroke in women using pills. Methods Case-case study was used. A total of 111 femalepatients with stroke were selected and with questionnaires filled in and blood sampies collected. Thedistributions of coagulative factor V Leiden mutation(G1691→A),prothrombin gene mutation(G20210→A) and angiotensin converting emzvrne (ACE) gene insertion/deletion(I/ D) polvrnorphisrn were observed. Differences of genetic; and nongenetic risk factors between hernorrhagic and ischaemicstroke were cornpared Results Women using pills had a higher risk developing hernorrhagic than ischaemic stroke (OR=3. 03,P< 0.O5),comparing with those never used pills. The strength of association between bodymass index(BMI)≥24 kg/m²-and ischaermic stroke was much greater than it between BMI andhemorrhagic stroke(OR=2. 99, P< 0.O5).No mutation of G1691→A or G20210→A was found. The deletion allele frequency of ACE gene was slightly higher in ischaemic stroke group, but with no statistic significance. Conclusion The Results suggested that possible association existed between the use of COC and the onset of hernorrhagic stroke however the mutations ofG1691→A in prothrombin gene and I/D polymorphism of ACE gene did not seem to contribate to this association

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