血管紧张素转换酶基因多态性与脑梗死危险因素的关系

张旭; 夏君慧; 金得辛; 林捷; 叶好好

Abstract

张旭,夏君慧,金得辛,林捷,叶好好.血管紧张素转换酶基因多态性与脑梗死危险因素的关系[J].Chinese journal of Epidemiology,2001,22(6):435-438

血管紧张素转换酶基因多态性与脑梗死危险因素的关系

The relationship between angiotensin converting enzyme gene polymorphism and risk factors for cerebralinfarct

Received:April 10, 2001

DOI：

KeyWord: 脑梗塞血管紧张素基因转换酶基因危险因素

English Key Word: Cerebral infarct Angio tensin-converting enzyme Genetics Risk factor

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Author Name	Affiliation
ZHANG Xu	Department of Neurology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China
XIA Junhui	Department of Neurology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China
JIN Dexin	Department of Neurology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China
林捷	Department of Neurology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China
叶好好	Department of Neurology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China

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Abstract:

　目的　探讨血管紧张素转换酶(ACE)基因多态性与中国汉族人脑梗死危险因素关系。方法　应用聚合酶链反应(PCR)，测定165 例脑梗死、101 例高血压患者和106 例正常对照者ACE 基因插入/ 缺失(I/D)多态性，用比色法测定血清ACE 水平，并调查脑梗死经典的危险因素。结果　脑梗死组DD 型基因频率为0.43，高于高血压组的0.31(χ2=4.03, P <0.05)和正常对照组的0.17(χ2 =19.86, P <0.01)，且D 等位基因亦明显高于高血压组和正常对照组(χ2 =7.14、32.85, P <0.01)。基底节、丘脑梗死者其DD 型基因频率和D 等位基因亦高于对照组(χ2 =18.30、12.41、29.00 、12.10，P <0.01)。脑梗死组血清ACE 水平明显高于正常对照组(F =2 240.06, P <0.01)，其中DD 基因型血清ACE 水平又高于同组DI 基因和II 基因(F =8.83, P <0.01)。结论　ACE 基因缺失多态性可能是中国人汉族脑梗死独立危险因素，循环ACE 活性与基因缺失多态性相关。

English Abstract:

Objective To ex plore the relationship be tw een angiotensin converting enzyme (ACE)gene polymo rphism and risk facto rs of cerebral infarct (CI)in Chinese Han nationality.Methods One hundred and six ty-five cases with cerebral infarct, 101 cases of essential hy pertensio n patients with 106 normal persons in Chinese Han serving as controls were detected using polymorase chain reactio n(PCR)and g enetic methods.ACE contents in serum w ere measured by colo rimetric method.Risk facto rs of cerebral infarct were assessed by standard questio nnaire, phy sical ex amination and blood tests.Results　ACE DD g enotype appeared mo re common in patients of cerebral infarct when comparing with essential hyper tension g roups (0.43 versus 0.31, χ2 =4.03, P <0.05)and normal contro ls (0.43 versus 0.17, χ2 =19.86, P < 0.01).D∶I allele frequency appeared to be 0.66∶0.34 in cerebral infarct patients and 0.41∶0.59 in controls (χ2 =32.85, P <0.01).I n basal ganglia infarct and thalamus infarct groups, ACE DD genotype and allele ratio distributio n were remarkably different to that in normal subjects (χ2=18.30, 12.41, P < 0.01).The mean levels of serum in cerebral and hypertension w ere hig her than in normal contro ls (F = 2 240.06, P <0.01), and serum ACE activity in ACE DD genotype was significantly higher than that in ACE DI and Ⅱ geno ty pe in cerebral group (F =8.83, P <0 01).Conclusions 　The ACE gene deletion polymorphism might serv e as an independent risk factor for cerebral infarct in Chinese Han nationality w hile circulation ACE activity might be related to gene deletion polymorphism

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