| 王薇,赵冬,刘军,柳洁,张振玲,刘静,刘飒,林铮,吴兆苏.北京城乡人群1168例血浆同型半胱氨酸分布及相关因素研究[J].Chinese journal of Epidemiology,2002,23(1):32-35 |
| 北京城乡人群1168例血浆同型半胱氨酸分布及相关因素研究 |
| The distribution of serum homocysteine and its associated factors in a population of 1 168 subjects in Beijing area |
| Received:May 27, 2001 |
| DOI： |
| KeyWord: 同型半胱氨酸 患病率 流行病学 |
| English Key Word: Homocysteine Prevalence rate Epidemiology |
| FundProject:北京心血管病研究实验室资助项目 ( 95 385 0 70 0 ) |
| Author Name | Affiliation | | WANG Wei | Department of Epidemiology,Institute of Beijing Heart Lung and Blood Vessel Diseases,Beijing 100029 | | ZHAO Dong | Department of Epidemiology,Institute of Beijing Heart Lung and Blood Vessel Diseases,Beijing 100029 | | LIU Jun | Department of Epidemiology,Institute of Beijing Heart Lung and Blood Vessel Diseases,Beijing 100029 | | LIU Jie | 北京安贞医院检验科 | | ZHANG Zhenling | 北京安贞医院检验科 | | LIU Jing | Department of Epidemiology,Institute of Beijing Heart Lung and Blood Vessel Diseases,Beijing 100029 | | LIU Sa | Department of Epidemiology,Institute of Beijing Heart Lung and Blood Vessel Diseases,Beijing 100029 | | LIN Zheng | 北京安贞医院分子生物学实验室, 100029 | | WU Zhaosu | Department of Epidemiology,Institute of Beijing Heart Lung and Blood Vessel Diseases,Beijing 100029 |
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| Abstract: |
| 目的描述北京地区人群血浆同型半胱氨酸(Hcy)水平及分布特点,分析Hcy与相关因素的关系。方法以北京地区城乡人群35～64岁男女两性1168人的调查结果为研究样本,对血浆同型半胱氨酸分布特点及与相关因素的关系进行统计学分析。结果①血浆Hcy几何均数男性为15.4μmol/L,女性为12.2μmol/L,男性高于女性(P<0.001)。②血浆Hcy分布存在着城乡差别,农村男性(18.0μmol/L)是城市男性(12.0μmol/L)的1.5倍(P<0.001),农村女性(12.9μmol/L)是城市女性(9.6μmol/L)的1.3倍(P<0.001)。③北京城乡35～64岁人群中高Hcy血症(Hcy≥16μmol/L)的患病率为15.3%。④与相关因素分析显示:城乡、性别、受教育水平和吸烟是高同型半胱氨酸血症的影响因素。结论北京地区人群血浆同型半胱氨酸水平的分布存在着年龄、性别和城乡间差别;北京地区人群Hcy水平及高Hcy血症的患病率明显高于西方发达国家,尤其是农村地区;城乡间Hcy水平的差别可能更大程度反映了环境因素的影响。 |
| English Abstract: |
| Objective To describe serum homocysteine distribution and its associated factors in population of urban and rural areas in Beijing. Methods The study population was represented by a randomly selected sample with 1 168 subjects, including both males and females aged 35-64. The levels of serum homocycteine were compared and the correlation with other risk factors were analyzed statistically. Results ①Geometric mean of serum homocycteine was 15.4 μmol/L in males and 12.2 μmol/L in females (P 0.001). ②There was a significant difference in homocysteine levels between urban population and rural population. Men from rural area had 1.5 times higher homocyteine than from urban ( 18.0 μmol/L vs 12.0 μmol/L,P 0.001), while the rural women had 1.3 times higher homocysteine level than urban women did. ③The prevalence rate of hyperhomocysteinemia was 15.3% in population aged 35-64 in Beijing area. ④Gender, residential location (urban or rural),smoking and education had independent effects on level of serum homocysteine by multivariate analysis. Conclusion Population in Beijing had higher serum level and prevalence rate of homocysteine than some western countries. Gender, geographic distribution, smoking and education had some influence on homocysteine level. |
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