新疆环境补碘对婴儿死亡和儿童发育的影响

任强; DeLong GR; 曹学义; 王少华; 姜新民; 蒋技勇; 马尔当; Karen O'Donnell

Abstract

任强,DeLong GR,曹学义,王少华,姜新民,蒋技勇,马尔当,Karen O'Donnell.新疆环境补碘对婴儿死亡和儿童发育的影响[J].Chinese journal of Epidemiology,2002,23(3):198-202

新疆环境补碘对婴儿死亡和儿童发育的影响

Effect of environmental supplementation of iodine on infant mortality and growth in children in Xinjiang, China

Received:January 17, 2002

DOI：

KeyWord: 环境补碘婴儿死亡儿童发育

English Key Word: Environmental iodine supplementation Infant mortality Child development

FundProject:

Author Name	Affiliation
REN Qiang	Institute of Population Research, Xinjiang University, Urumqi 830046, China
DeLong GR	美国杜克大学医学中心
CAO Xueyi	新疆维吾尔自治区卫生防疫站
WANG Shaohua	新疆维吾尔自治区卫生厅
JIANG Xinmin	新疆维吾尔自治区地方病研究所
JIANG Jiyong	新疆维吾尔自治区地方病研究所
MA Erdang	新疆维吾尔自治区地方病研究所
Karen O'Donnell	美国杜克大学医学中心

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Abstract:

目的　研究新疆环境补碘新方法对婴儿死亡和儿童发育的影响. 方法　用补碘前和补碘后2乡历年5岁儿童尿碘、身高和头围监测资料, 以美国同龄儿童为参照计算Z得分. 用logistic回归方法分析4乡3县1988～1999年的婴儿死亡和新生儿死亡数据. 结果　环境补碘后婴儿死亡相对风险比降低了56. 49%, 新生儿死亡相对风险比降低了65. 71%;控制是否补碘变量后, 实验区和对照区婴儿死亡或新生儿死亡差异无显著性. 朗如乡5岁儿童平均身高由1992年的95cm提高到1998～1999年的106. 9cm;同期平均头围由48. 4cm提高到50. 5cm;尿碘中位值由补碘前低于10μg/L提高到176μg/L. 巴克其乡5岁儿童平均身高由1993年的91cm提高到1998～1999年的106. 5cm;同期平均头围由48. 7cm提高到49. 6cm;尿碘中位值由39μg/L提高到138μg/L. 结论　新疆和田地区的环境补碘方法显著地降低了婴儿、新生儿死亡率, 极大地改善了儿童的生长发育状况.

English Abstract:

Objective To study the effect of iodine supplementation on infant mortality and growth in Xinjiang. Methods Urine iodine, height and head circumference (HC) of children aged 5 years in two townships was measured before and yearly after iodine supplementation of irrigation water. Height and HC were expressed as Z scores (United States children used as the reference group). Neonatal and infant mortality rates were obtained from official records in three counties from 1988 to 1999, and analyzed by a logistic regression model. Results The odds ratio of infant mortality decreased 56. 49 % and neonatal mortality 65. 71 % respectively after iodination; there was no significant difference in the odds ratio of infant or neonatal mortality between experimental and control areas without iodination. In Langru township, the mean height of 5 year old children increased from 95 cm in 1992 to 106. 9 cm in 1998 1999, and HC from 48. 4 cm to 50. 5 cm. Median urine iodine increased from 10 to 176 μg/L. In Bakechi township, mean height increased from 91 cm in 1993 to 106. 5 cm in 1998 1999, HC from 48. 7 to 49. 6 cm, and median urine iodine from 39 to 138 μg/L. Conclusion In Xinjiang, adequate iodine treatment markedly decreased infant and neonatal mortality, and largely preventing stunting of height and HC in children.

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