多巴胺受体D2基因多态性与吸烟行为及肺癌风险的相关性

齐军; 谭文; 邢德印; 缪小平; 林东昕

Abstract

齐军,谭文,邢德印,缪小平,林东昕.多巴胺受体D2基因多态性与吸烟行为及肺癌风险的相关性[J].Chinese journal of Epidemiology,2002,23(5):370-373

多巴胺受体D2基因多态性与吸烟行为及肺癌风险的相关性

Study on the association between smoking behavior and dopamine receptor D2 gene polymorphisms among lung cancer cases

Received:December 28, 2001

DOI：

KeyWord: 多巴胺受体D2 吸烟行为肺肿瘤

English Key Word: Dopamine D2 receptor Smoking behavior Lung neoplasms

FundProject:国家杰出青年科学基金资助项目 (39825122)

Author Name	Affiliation
QI Jun	Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
TAN Wen	肿瘤研究所病因及癌变研究室
XING Deyin	肿瘤研究所病因及癌变研究室
MIAO Xiaoping	肿瘤研究所病因及癌变研究室
LIN Dongxin	肿瘤研究所病因及癌变研究室

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Abstract:

目的探讨多巴胺受体D2(DRD2)基因多态性在汉族人群中的分布及其与吸烟行为和肺癌风险的关系。方法用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析方法,检测326名正常人群和326例肺癌病人DRD2基因TaqIA和TaqIB多态频率。结果在对照人群中,DRD2A1和A2等位基因频率分别为41.3%和58.7%,B1和B2基因频率分别为43.6%和56.4%。DRD2基因多态与吸烟与否和吸烟年数无明显相关。然而,在日吸烟量≥25支的吸烟者中,A2/A2和B2/B2基因型频率分别为42.5%和40.0%,高于日吸烟量<25支的吸烟者(26.1%;P=0.047和0.091)。肺癌病人中吸烟者的比例显著高于正常对照,但两组的DRD2基因型频率差异无显著性。结论DRD2A2/A2基因型可能与吸烟成瘾性有一定关系,但尚需更大样本量的独立研究加以证实。

English Abstract:

Objective To investigate the possible association between dopamine D2 receptor (DRD2) TaqI A and TaqI B genotypes as well as smoking behavior and the risk of lung cancer among Chinese Han people. Methods PCR was used to perform genotyping on peripheral WBC DNA from 326 lung cancer patients and 326 age, sex and ethnicity matched healthy controls. Subjects were interviewed to obtain relevant information and lifetime history of tobacco use. Results There were no statistically significant differences in the distribution of DRD2 genotypes between lung cancer cases and controls. The DRD2 genotypes and smoking status showed no correlation among cases and among controls as well. However, among controls, the frequency of the DRD2*A2/A2 genotype in smokers who smoked ≥25 cigarettes/day appeared to be higher than that in those who smoked 25 cigarettes/day ( 42.5 % versus 26.1 %, P = 0.047 ). A similar trend was also found for the DRD2*B2/B2 genotype, which was linked to the DRD2*A2/A2 genotype, although the difference was not significant ( 40.0 % versus 26.1 %, P = 0.091 ). In contrast to controls, no association was found between the DRD2 genotypes and smoking among lung cancer cases. Conclusion Our results suggested that DRD2*A2/A2 genotype might be associated with a greater smoking intensity in Chinese.Further studies are needed to confirm this preliminary finding.

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