原发性肝癌与出生顺序的研究

蔡如琳; 孟炜; 陆鸿雁; 江峰; 姜庆五; 林文尧; 沈福民

Abstract

蔡如琳,孟炜,陆鸿雁,江峰,姜庆五,林文尧,沈福民.原发性肝癌与出生顺序的研究[J].Chinese journal of Epidemiology,2003,24(1):22-25

原发性肝癌与出生顺序的研究

A study on the relationship of birth order hepatocellular carcinoma

Received:June 26, 2002

DOI：

KeyWord: 肝细胞瘤出生顺序家系研究

English Key Word: Hepatoma Bir th order Pedig ree study

FundProject:国家自然科学基金资助项目(39930160)

Author Name	Affiliation	E-mail
Cai Ru-lin	Department of Epidemiology, Public Health School of Fudan University, Shanghai 200032, China
Meng Wei	Department of Epidemiology, Public Health School of Fudan University, Shanghai 200032, China	wmeng@shmu.edu.cn
Lu Hong-yan	江苏省海门市卫生防疫站, 海门 226100
Jiang Feng	Department of Epidemiology, Public Health School of Fudan University, Shanghai 200032, China
Jiang Qing-wu	Department of Epidemiology, Public Health School of Fudan University, Shanghai 200032, China
Lin Wen-yao	江苏省海门市卫生防疫站, 海门 226100
Shen Fu-min	Department of Epidemiology, Public Health School of Fudan University, Shanghai 200032, China

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Abstract:

目的: 分析原发性肝癌患者的出生顺序, 探讨环境因素与肝癌的关系。方法: 根据Greenwood及Haldane的出生顺序方法, 对来自江苏省海门市8年随访队列的100个家系中100例先证者及22例患病同胞进行出生顺序研究。结果: Greenwood法分析结果显示, 患者出生顺序在1～3胎次的个体较多, 当控制了乙型肝炎病毒感染的影响后, 结果仍显示肝癌病人好发在出生顺序较早的个体。 Haldane法计算∑6A_实际值 =180 6,∑ 6A_理论值 =1988, 实际6A值与期望6A值相差两个标准差以上,︱∑ 6A_实际值 -∑ 6A_理论值︱/∑V6A =2.1657, 差异有显著的统计学意义(0.02结论: 肝癌的发生与出生顺序有关, 发生在出生较早的个体, 这与国外报道的肝癌好发于出生顺序较晚个体的结论不一致。生态学研究表明, 长期饮用沟塘水与肝癌好发在出生顺序较早的个体有关, 提示环境因素对肝癌的发生有一定的影响。

English Abstract:

Objective: To explore the association of hepatocellular carcinoma (HCC) with environmental factors throug h analy zing birth order data from pedigree sibships. Methods: A birth order study was conducted based on the methods of Greenwood and Haldane for 100 probands and 22 affected siblings from 100 pedigrees in a cohort which was followed up for 8 years in Haimen, Jiangsu, China. Results: The findings from the Greenwood method suggested that there was a tendency for cases of HCC to concentrate at lower birth orders of 1 to 3. With the effects of hepatitis B virus on the birth orders being controlled, the same tendency was also observed. The results from Haldane method showed that difference between actual value and expected value of 6A was more than the double standard deviation. Σ 6A _{actual value}=1 806, Σ 6 A _{expected value} =1988, ︱Σ 6 A_{actual value} - Σ 6 A _{expected value}︱/ Σ V6 A =2.1657(0.02

Conclusions: There was a tendency that the onset of HCC cases concentra ting was at lower birth orders in this research, which was inconsistent with several reports of foreign authors' which showed a reverse tendency. According to the ecological results, it was suggested that long-term drinking of ditch-water was responsible for the tendency of cases of HCC concentrating at lower birth orders. There were also certain effects of environmental factors exerted on the onset of HCC being discovered.

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