| 刘玮,张翠英,吴晓明,田磊,李春芝,赵秋敏,张泮河,杨淑梅,杨红,张习坦,曹务春.维生素D受体基因多态性与肺结核易感性的病例对照研究[J].Chinese journal of Epidemiology,2003,24(5):389-391,392 |
| 维生素D受体基因多态性与肺结核易感性的病例对照研究 |
| A case-control study on the vitamin D receptor gene polymorphisms and susceptibility to pulmonary tuberclosis |
| Received:July 30, 2002 |
| DOI： |
| KeyWord: 结核,肺 维生素D受体基因 病例对照研究 |
| English Key Word: Tuberculosis,pulmonary Vitamin D receptor gene Case-control study |
| FundProject:国家自然科学基金资助项目 (30271144) |
| Author Name | Affiliation | | LIU Wei | Epidemiological Department of Institute of Microbiology and Epidemiology,Academy of Military Medical Sciences,Beijing 100071,China | | ZHANG Cui-ying | 解放军第三○九医院 | | WU Xiao-ming | Epidemiological Department of Institute of Microbiology and Epidemiology,Academy of Military Medical Sciences,Beijing 100071,China | | TIAN Lei | 解放军第九一医院 | | LI Chun-zhi | 解放军总参三部防疫队 | | ZHAO Qiu-min | Epidemiological Department of Institute of Microbiology and Epidemiology,Academy of Military Medical Sciences,Beijing 100071,China | | ZHANG Pan-he | Epidemiological Department of Institute of Microbiology and Epidemiology,Academy of Military Medical Sciences,Beijing 100071,China | | YANG Shu-mei | 解放军总参三部防疫队 | | YANG Hong | Epidemiological Department of Institute of Microbiology and Epidemiology,Academy of Military Medical Sciences,Beijing 100071,China | | ZHANG Xi-tan | Epidemiological Department of Institute of Microbiology and Epidemiology,Academy of Military Medical Sciences,Beijing 100071,China | | CAO Wu-chun | Epidemiological Department of Institute of Microbiology and Epidemiology,Academy of Military Medical Sciences,Beijing 100071,China |
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| Abstract: |
| 目的探讨维生素D受体(VDR)基因多态性与中国汉族人群肺结核发病间的关系。方法采用病例对照研究设计,用聚合酶链反应限制性片段长度多态性分析(PCRRFLP)检测VDR基因中T/C多态性位点,对肺结核相关的环境因素进行问卷调查,并进行单因素分析和多因素logistic回归分析。结果对76例病例和171名对照进行了VDR的基因分型,VDRFF、VDRFf与VDRff三种基因型在病例组和对照组中的分布频率分别为38.2%、44.7%、17.1%和52.6%、40.9%、6.4%,其中ff基因型在病例组中的频率显著高于对照组,OR值95%CI:3.668(1.483～9.071);在多因素分析中调整卡介苗接种史和吸烟状况后,VDRff基因型与肺结核发病仍有显著性关联,调整OR值95%CI:3.036(1.117～8.253)。结论VDRff基因型可能是中国汉族人群肺结核病的易感基因型。 |
| English Abstract: |
| Objective To investigate the association between the genetic polymorphisms of VDR gene and susceptibility to pulmonary tuberculosis .Methods Case-control study w as conducted.PCR-RFLP technique was used to detect the C/ T polymorphism in VDR gene.Information on related factors of tuberculosis was collected using a pre-tested questionnaire.Univariate and multivariate logistic analyses were conducted with SPSS software package.ResultsA sample of 76 cases and 171 controls w as studied.The genotype frequencies of VDR-FF,VDR-Ff and VDR-ff were 38.2%,44.7%,17.1% and 52.6%,40.9%,6.4% respectively.VDR-ff was significantly overrepresented in case group,the OR(95%CI) was 3.668(1.483-9.071)when comparing with FF genotype.The significant association remained after adjusting BCG immunization and smoking,the OR (95%CI)was 3.036(1.117-8.253).ConclusionThe VDR-ff genotype might be associated with the susceptibility to pulmonary tuberculosis in Chinese Han population. |
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