浙江海岛渔民人群吸烟、饮酒与高脂血症的关系

王建跃; 张立军; 水黎明; 陈坤; 鄢盛凯; 杜虹; 曾武威; 吴钢; 薛红; 陈保生

Abstract

王建跃,张立军,水黎明,陈坤,鄢盛凯,杜虹,曾武威,吴钢,薛红,陈保生.浙江海岛渔民人群吸烟、饮酒与高脂血症的关系[J].Chinese journal of Epidemiology,2003,24(12):1115-1117

浙江海岛渔民人群吸烟、饮酒与高脂血症的关系

Study on the relationship between smoking, alcohol intake and hyperlipidemia in fishermen

Received:January 12, 2003

DOI：

KeyWord: 吸烟饮酒高胆固醇血症高甘油三酯血症

English Key Word: Smoking Alco hol intake Hy percholesterolemia Hypertrigly ceridemia

FundProject:浙江省医药卫生优秀青年人才专项科研基金资助项目

Author Name	Affiliation
Wang Jianyue	Center for Disease Control and Prevention of Zhoushan City, Zhoushan 316000, China
Zhang Lijun	Center for Disease Control and Prevention of Zhoushan City, Zhoushan 316000, China
Shui Liming	浙江大学公共卫生学院
Chen Kun	浙江大学公共卫生学院
Yan Shengkai	北京协和医院
Du Hong	暨南大学附属第二医院
Zeng Wuwei	中国医学科学院协和医科大学
Wu Gang	中国医学科学院协和医科大学
Xue Hong	中国医学科学院协和医科大学
Chen Baosheng	中国医学科学院协和医科大学

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Abstract:

目的探讨渔民人群吸烟、饮酒与高胆固醇血症、高甘油三酯血症之间的关系。方法应用现况调查结合病例对照研究的方法,随机抽取 115名海岛渔民,按血脂检测结果分为病例组和对照组。采用流行病学问卷调查表的形式,详细调查其个人一般情况及吸烟、饮酒史,用单因素及其统计学分析方法比较吸烟 (饮酒 )组与对照组间脂蛋白和载脂蛋白 (apo)水平差异及吸烟和饮酒对高脂血症的OR值。结果吸烟组的OR值为 3.4 17(95 %CI∶1.132～ 10.30 8),吸烟指数与高脂血症患病具有明显的剂量效应关系,吸烟组低密度脂蛋白胆固醇 (LDL C)和apoB的水平高于对照组。开始饮酒年龄≤ 2 0岁及年饮酒精量≥ 15 0 0 0ml者,对高脂血症的OR值分别为 4.016 (95 %CI :1.475～10.952 )及 3.275 (95 %CI:1.249～ 8.580 ),酗酒渔民LDL C、apoB、总胆固醇 (TC) /高密度脂蛋白胆固醇 (HDL C)水平高于对照组,吸烟且饮酒者其OR值高于单吸烟或单饮酒者。结论吸烟和酗酒是高脂血症的重要危险因素,其主要通过影响LDL C、apoB水平导致高脂血症发生。吸烟及酗酒对高脂血症的发生具有协同作用。

English Abstract:

Objective To identify the relationship be tw een smoking, alcohol intake and hyperlipidemia in fishermen.Methods 115 fishermen were randomly recruited and divided into case and control groups according to the result of bloo d lipoprotein.A questionnaire was used to record generalinformation and the history o f smo king and alco hol intake.Statistics were gathered to compare the difference of lipoprotein and apolipoprotein lev el between expo sure and control groups and to calculate the OR value of smo king and alcohol intake.Results The OR of smo king w as 3.417(95 %CI :1.132-10.308), with significant dosag e-effect relationship between smoking index and hyperlipidemia.The serum low density lipopro teincholesterol(LDL-C) and apolipopro tein(apo)B lev els in smoking g roup was higher than that of control g roup.The OR value of alcohol intake at early age(early than 20)were 3.275(95 %CI :1.249-8.580) and 4.016(95%CI :1.475-10.952) respectively.The LDL-C, apoB, the serum to talcholesterol(TC)/ hig h density lipo protein-cholesterol(HDL-C) levels in alcohol abuse g roup were higher than that of control g roup.Conclusion Smoking and alcohol abuse w ere impor tant risk factors of hyperlipidemia, throug h changing the level o f LDL-C and apoB.There w as sy nergistic action between smoking and alcohol abuse in the development of hyperlipidemia

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