| 成金罗,沈默宇,周玲,王劲松.125个家族高发性2型糖尿病的危险因素研究[J].Chinese journal of Epidemiology,2004,25(2):162-164 |
| 125个家族高发性2型糖尿病的危险因素研究 |
| A study on risk factors among 125 type 2 diabetes mellitus with familial tendency |
| Received:April 24, 2003 |
| DOI： |
| KeyWord: 糖尿病，2型 危险因素 遗传度 |
| English Key Word: Diabetes mellitus,type 2 Risk factors Heritability |
| FundProject:江苏省社会发展基金(BS200031) |
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| Abstract: |
| 目的 研究家族高发性2型糖尿病家系人群中可能的遗传和环境危险因素。方法 对1999～2001年门诊及住院的125个家庭高发性2型糖尿病先证者的家庭成员调查家族信息和环境危险因素,比较2型糖尿病患者、糖耐量减低(IGT)患者与非患者在环境危险因素的差异。采用Falconer法估算遗传度,用Penrose法进行多基因分析研究其遗传危险性。结果 三组人群甘油三酯、体重指数、腰臀比值、高血压史及体力活动史的构成比差异有极显著性(P<0.01),而其他血脂项目及冠心病史差异未见显著性。125个大家系的2型糖尿病遗传度为83.42％±5.84％,提示在这些家系中可能有显性主基因存在。多基因分析研究表明在该人群中,2型糖尿病可能符合多基因遗传模式。结论 2型糖尿病为多基因疾病,环境危险因素和遗传因素及其交互作用可能影响其发病。 |
| English Abstract: |
| Objective To study the risk factors regarding heredity and environment in familial incident type 2 diabetes mellitus (DM). Methods To compare the difference of environmental risk factors between type 2 DM, impaired glucose tolerance (IGT) and normal persons through study on familial information and environmental risk factors in 125 familial incident type 2 DM in-patients and out-patients from 1999 to 2001. Falconer was used to estimate heritability. Penrose was used to study the heredity damagers by polygene analysis. Results There was a significant constiuent ratio diversity (P 0. 01) in triglyceride, body mass index, waist to hip ratio, hypertension history and physical activities history among 3 groups, while no significant diversity in blood lipids and history of coronary heart disease. 83. 42%± 5. 84% heritability of type 2 DM in 125 familial predigree indicated that dominant major gene might exist in these familiar pedigrees. Analysis of polygene in these groups showed type 2 DM might conform to the model of polygene heredity. Conclusion This study suggested that type 2 DM had significant heritability and genetic heterogeneity, which generally appeared to be a disease of multi--factorial inheritance. Environmental risk factors, genetic factors and their interactions were due to type 2 DM. |
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