耐甲氧西林金黄色葡萄球菌对碘伏和氯已定抗性的研究

张艳红; 刘秀岩; 朱莉莉; 俞幼知

Abstract

张艳红,刘秀岩,朱莉莉,俞幼知.耐甲氧西林金黄色葡萄球菌对碘伏和氯已定抗性的研究[J].Chinese journal of Epidemiology,2004,25(3):248-250

耐甲氧西林金黄色葡萄球菌对碘伏和氯已定抗性的研究

Study on the resistance of methicillin--resistant staphylococcus aureus to iodophor and chlorhexidine

Received:January 13, 2003

DOI：

KeyWord: 耐甲氧西林金黄色葡萄球菌碘伏最低抑菌浓度

English Key Word: Methicillin-resistant staphylococcus aureus Iodophor Minimal ibhibitory concentration

FundProject:江苏省应用基础基金(BJ1998030)

Author Name	Affiliation
ZHANG Yan-hong	The First Hospital Affiliated to Nanjing Medical University, Nanjing 210029 China
LIU Xiu-yan	The First Hospital Affiliated to Nanjing Medical University, Nanjing 210029 China
ZHU Li-li	The First Hospital Affiliated to Nanjing Medical University, Nanjing 210029 China
YU You-zhi	中国疾病预防控制中心传染病预防控制所

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Abstract:

目的<\b> 了解临床分离的耐甲氧西林的金黄色葡萄球菌(MRSA)对医院常用消得剂的抗性。方法<\b> 测定碘伏和氯已定对MRSA、甲氧西林敏感的金黄色葡萄球菌(MSSA)和金鱼色葡萄球菌ATCC6538的最小抑菌浓度(MIC)。结果<\b> 碘伏对MRSA的MIC明显高于MSSA,在38株MRSA中5.3％菌株的MIC是质控菌株的2倍,28.95％菌株的MIC为质控菌株的1.5倍,而18株MSSA中仅有11.1％菌株的MIC是质控菌株的1.5倍,83.3％菌株的MIC值与质控菌株相同。醋酸氯已定对MRSA、MSSA和金黄色葡萄球菌ATCC6538的MIC值相同。结论<\b> 部分MRSA菌株对碘伏抗性增高,MRSA对氯已定的抗性无明显增强,因此当有抗性菌株存在时应提高碘伏的浓度

English Abstract:

Objective<\b> To study the resistance of methicillin--resistant staphylococcus aureus (MRSA),an indicator used in hospitals. Methods<\b> We used minimal inhibitory concentrations(MIC) of iodoph and chlorhexidine to MRSA, methicillin--sensitive staphylococcus aureus (MSSA) and staphylococcus aures ATCC6538. Results<\b> Obvious difference between MRSA and MSSA the MIC of lodophor was noticed. Among MICs, 5. 3 % MRSA strains were 2--folds and 28. 9 % MRSA strains were 1. 5 fold more than staph. aures ATCC6538, while the MIC of 11. 1 % MSSA strains raised 1. 5 fold than ATCC6538. The MIC of 83. 3 % MSSA strains were the same to staph. aureus ATCC6538. The MIC of chlorhexidine to MRSA, MSSA and staphyloccus aureus ATTC6538 were similar to each other. Conclusion<\b> Results<\b> showed that some MRSA were more resistant to Iodophor than staph. aureus ATCC6538, but remained the same resistance to Chlorhexidine. Thus the concentrationn of Iodophor should be raised when the resistant strains were isolated.

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