| 毛宇嵘,郑锡文,热孜燕,潘承东,古丽肉孜,宋俊青,杨丽敏,张桂云.新疆伊宁市婚检人群婚后艾滋病病毒性传播研究[J].Chinese journal of Epidemiology,2004,25(4):322-324 |
| 新疆伊宁市婚检人群婚后艾滋病病毒性传播研究 |
| An epidemiological study on sexual transmission of human immunodeficiency virus among pre-marital group in Yining city, Xinjiang |
| Received:January 08, 2003 |
| DOI： |
| KeyWord: 艾滋病病毒 性传播 婚检人群 发病密度 比例风险模型 |
| English Key Word: Human immunodeficiency virus Sexual transmission Pre-marital couples Incidence density Proportional hazard model |
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| Abstract: |
| 目的 了解伊宁市艾滋病病毒(HIV)经异性性传播状况。方法 对1997年1月1日至2000年12月31日间婚检查出的HIV感染者及其阴性配偶建立队列,运用比例风险模型进行HIV抗体阳转时间及其影响因素的研究,研究对象做到知情同意。结果 通过对22对血清HIV抗体检测结果不一致夫妻的随访研究发现,婚后HIV阴性一方通过夫妻性传播感染HIV的发病密度为32.49/100人年,女性通过性传播感染HIV的发病密度为33.74/100人年。比例风险模型分析显示,HIV感染者配偶的阳转时间较短,平均HIV抗体阳转时间仅为2.43年。性生活频次为HIV感染者配偶HIV抗体阳转的主要影响因素(≥3次/周和<3次/周:RR=1.984,95%CI:1.045～3.767)。病毒载量对于夫妻性传播的影响并不显著。HIV抗体阳转的配偶的CD4+/CD8+比值显著低于未阳转者(t=4.77,P<0.01)。结论 新疆伊宁市婚检人群中HIV感染率较高且逐年上升,该地区已进入艾滋病高流行期。建议在HIV高流行性地区开展婚前HIV咨询和检测,同时加强婚检制度的管理,以控制HIV向一般人群中的进一步传播。 |
| English Abstract: |
| Objective To study the human immunodeficiency virus (HIV) status through heterosexual transmission in Yining city and to provide information on effective intervention measures. Methods Cohort of HIV sero-discordant couples identified from 1997 to 2000 was formed. Proportional risk model was used to analyze the time of HIV sero-conversion and the related factors. All the recruiters were under informed consent. Results Through following on 22 sero-discordant couples, we found that the incidence density (ID) of HIV sero-conversion was 32. 49/100 person-year (PY) with 33. 74/ 100 PY for women. In the proportional hazard model, the course of sero-conversion was only 2. 43 years and the frequency of sexual contact was statistically significant (≥3 times/week vs. 3 time/week: RR=1.984, 95% CI:1.045-3. 767), indicating this factor was related to the hazard of HIV sero-conversion. However, the viral load of HIV infections has no such effect on HIV sero-conversion of their spouses. In addition, the ratio of CD4+ /CD8+ was lower in spouses of HIV sero-conversion than that in spouses of HIV non-sero conversion (t test:t=4.77, P0.01). Conclusion In order to control HIV transmission among general population, we suggested that HIV/AIDS counseling and testing be developed for pre-marital people in the region with high HIV prevalence |
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