| 李荣成,杨进业,龚健,李艳萍,黄兆能,方孔雄,徐志一,刘崇柏,赵铠,庄辉.乙型肝炎疫苗接种预防乙型肝炎和肝癌效果[J].Chinese journal of Epidemiology,2004,25(5):385-387 |
| 乙型肝炎疫苗接种预防乙型肝炎和肝癌效果 |
| Efficacy of hepatitis B vaccination on hepatitis B prevention and on hepatocellular carcinoma |
| Received:March 10, 2004 |
| DOI： |
| KeyWord: 乙型肝炎 疫苗 乙型肝炎表面抗原 |
| English Key Word: Hepatitis B vaccine Hepatitis B surface antigen |
| FundProject: |
| Author Name | Affiliation | | Li Rong-cheng | Center for Disease Prevention and Control, Guangxi Zhuangzu Autonimous Region, Nanning 530021, China | | Yang Jin-ye | Center for Disease Prevention and Control, Guangxi Zhuangzu Autonimous Region, Nanning 530021, China | | Gong Jian | Center for Disease Prevention and Control, Guangxi Zhuangzu Autonimous Region, Nanning 530021, China | | Li Yan-ping | Center for Disease Prevention and Control, Guangxi Zhuangzu Autonimous Region, Nanning 530021, China | | Huang Zhao-neng | 隆安县疾病预防控制中心 | | Fang Kong-xiong | 隆安县疾病预防控制中心 | | Xu Zhi-yi | 复旦大学医学院 | | Liu Chong-bai | 中国疾病预防控制中心病毒病预防控制所 | | Zhaao Kai | 卫生部北京生物制品研究所 | | Zhuang Hui | 北京大学医学部 |
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| Abstract: |
| 目的: 评价乙型肝炎(乙肝)疫苗预防乙肝和原发性肝细胞癌(肝癌)的保护效果。方法: 采用出生队列调查、横断面血清流行病学调查以及乙肝发病和肝癌死亡监测, 对乙肝疫苗的预防效果进行评价。结果: 婴儿乙肝疫苗普种后14年, 接种人群HBsAg阳性率为0.7%～2.9%(平均为1.5%), 保护率为83.5%～96.6%; HBV感染率为1.1%～5.1%(平均为2.2%), 保护率为93.5%～98.4%。乙肝疫苗普种后15年, 1～14岁年龄组乙肝发病率为1.4/10万, 下降92.4%; 0～19岁组肝癌死亡率为0.17/10万, 下降19.23倍。结论: 婴儿乙肝疫苗普种可降低急性乙肝发病率和肝癌死亡率。 |
| English Abstract: |
| Objective: To evaluate the efficacy of hepatitis B vaccination on hepatitis B preventin and on hepatocellular carcinoma. Methods: Birth cohort study cross-sectional seroepidemiological survy, and surveillance of hepatitis B (HBV) and hepatocellular carcinoma were used to evaluate the efficacy of hepatitis B vaccination. Results: During the 14 years after hepatitis B vaccination, the HBsAg positive rates were found to be 0.7%-2.9%, with an average of 1.5%, and the protective rates were 83.5%-96.6%. Hepatitis B virus infection rates of children immunized with hepatitis B vaccine were 1.1%-5.1%, with an average of 2.2% and the protective rates of 93.5%-98.4%. 15 years after hepatitis B vaccination, the incidence of hepatitis B dropped from 3.27/10000 to 0.17/10000, a 94.8% decrease, in the group of 0-19 year-olds. Conclusion: The universal infant infant hepatitis B vaccination has proved to be effective in reducing the incidence rate of acute hepatitis B as well as the mortality of hepatocellular carcinoma. |
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