| 王蓓,汪宁,金辉,顾红英,宋晓波,武庆斌,丁慧,沈蕙,高倩,吴盛辉,PaulE.Kilgore.不同地区婴幼儿轮状病毒感染性腹泻的流行病学研究[J].Chinese journal of Epidemiology,2004,25(9):737-740 |
| 不同地区婴幼儿轮状病毒感染性腹泻的流行病学研究 |
| Epidemiological study on rotavirus-borne diarrhea in infants and children in different areas |
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| DOI： |
| KeyWord: 轮状病毒感染|腹泻|流行病学|婴幼儿 |
| English Key Word: Rotavirus infections|Diarrhea|Epidemiology|Infant and children |
| FundProject:国际疫苗研究所及东南大学科学基金(XJ0190O1) 资助项目 |
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| Abstract: |
| 目的 分析比较不同地区婴幼儿轮状病毒(RV)感染性腹泻的流行病学特征. 方法 于2001年9月至2003年9月在江苏省苏州市和安徽省马鞍山市各选择一所医院建立临床监测哨点, 以临床就诊的＜5岁腹泻患儿为研究对象, 用酶联免疫吸附试验检测RV抗原, 同时采用逆转录聚合酶链反应对RV毒株进行血清型与基因型的鉴定. 结果 (1)两地区RV感染均呈现明显的秋冬季节性, 但季节高峰有所不同, 高峰季节的感染率可达50%～80%; (2)两地区腹泻患儿RV感染率差异具有统计学意义, 住院腹泻患儿的平均感染率分别为47.28%和30.38%, 门诊腹泻患儿平均感染率分别为28.39%和14.77%; (3)两地区RV的感染率均表现出年龄分布的不同, 以6～35月龄组较高, 无性别差异; (4)苏州市的两个流行高峰均以G3型为主, 其次是G1型; 马鞍山市第一个流行高峰以G1型为主, 第二个高峰则以G3型为主; 两地区流行株的G/P组合型与国内外有所不同. 结论 婴幼儿RV腹泻在地区、时间以及病毒流行株分布等方面各有不同, 提示RV感染的监测工作对其疫苗的研制和应用具有重要的指导作用. |
| English Abstract: |
| To analyze and compare the epidemiological features of rotavirus diarrhea among infants in the different areas so as to provide data fur rotavirus vaccine research. Methods From Sep.2001 through Sep.2003, sentinel sites were set up in Suzhou Children's Hospital and Maanshan Hospital. Fecal samples from children(<5 years) with acute diarrhea were collected and enzyme linked immunosorbent assay was used to detect rotavirus antigen. Reverse transcription-polymerase chain reaction was used to determine the G serotypes and P genotypes of rotavirus strains. The features of strains in the two places and other areas of China were analyzed and compared. Results(1)Rotavirus infection appeared in autumn and winter, but the peaks varied. In Suzhou the peaks were from December to next February in 2001, and November to next January in 2002. But in Maanshan, it was November to next January for both two years. (2)Rate of rotavirus infection in Suzhou was much higher than that in Maanshan, infective rates of Inpatient Department and Outpatient Department are 47.28%. 28.39 % and 30.38%, 14.77%respectively in the two hospitals. (3)Rates of infection in two hospitals showed age difference but the highest group was in 6-35 month-olds. No gender difference was found. (4) Secular distribution of G-typing and P-typing of rotavirus strain was different in Suzhou and Maanshan. G3 was mainly found in Suzhou and Gl in Maanshan. From 2002-2003 on, G3 became dominant in Maanshan. Conclusion Rotavirus caused diarrhea among infant and children were different in terms of areas, period and types, suggesting that the introduction of rotavirus vaccine should be adjusted according to different strains with specific types and optimal timeline. |
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