| 高莉洁,赵仲堂,李栋,姜宝法,郝凤荣.中枢神经系统先天畸形危险因素的病例对照研究[J].Chinese journal of Epidemiology,2004,25(9):794-798 |
| 中枢神经系统先天畸形危险因素的病例对照研究 |
| A case-control study on the risk factors of central nervous system congenital malformations |
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| DOI： |
| KeyWord: 中枢神经系统|畸形|危险因素|病例对照研究 |
| English Key Word: Central nervous system|Malformations|Risk factors|case-control study |
| FundProject:山东省“十大示范工程”资助项目(04010173) |
| Author Name | Affiliation | | GAO Li-ye | Institute of Epidemiology and Health Statisti, School of Publii Health, University of Shandong. Jinan 250012, China | | ZHAO Zhong-tang | Institute of Epidemiology and Health Statisti, School of Publii Health, University of Shandong. Jinan 250012, China | | LI Dong | 泰山医学院预防医学教研室 | | JIANG Bao-fa | Institute of Epidemiology and Health Statisti, School of Publii Health, University of Shandong. Jinan 250012, China | | HAO Feng-rong | Institute of Epidemiology and Health Statisti, School of Publii Health, University of Shandong. Jinan 250012, China |
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| Abstract: |
| 目的 探讨与中枢神经系统(CNS)先天畸形发生有关的危险因素. 方法 以医院为基础的1∶2配比病例对照研究方法, 对照匹配的条件为同性别、同一居住地区与出生日期相差6个月, 采用单因素及多因素logistic回归分析方法对48个变量进行分析. 结果 母亲孕期接触农药(OR=16.471)、母亲孕期感冒发烧(OR=12.621)、先天畸形家族史(OR=10.246)、母亲孕期多食腌菜或泡菜(OR=7.274)、父亲接触有害化学物(OR=5.616)、母亲孕期有负性生活事件(OR=3.730)与 CNS先天畸形的发生有正相关, 母亲孕期多食肉、蛋、豆、奶类食物(OR=0.229)与CNS先天畸形的发生有负相关. 结论 CNS先天畸形是多因素疾病, 母亲孕期接触农药、母亲孕期感冒发烧、先天畸形家族史、母亲孕期多食腌菜或泡菜、父亲接触有毒化学物、母亲孕期有负性生活事件是其危险因素, 母亲孕期多食肉、蛋、豆、奶类食物是保护因素. |
| English Abstract: |
| Objective To determine the risk factors in the development of central nervous system (CNS)congenital malformations. Methods A hospital-based 1:2 matched case-control study was conducted. Each case was matched with two normal controls on sex and residential area, date of birth, within half a year. By means of simple and multivariable conditional logistic regression, 48 factors were analyzed. Results Maternal exposure to pesticide or having cold with fever, family history of positive congenital malformations, preference eating pickled vegetables, negative life events, large consumption of meat,eggs.beans and milk during pregnancy and paternal exposure to poisonous chemicals were significantly associated with CNS congenital malformations, with odds ratios 16.471, 12.621, 10.246, 7.274, 3.730, 0.229, 5.616, respectively. Conclusions Maternal exposure to pesticides, cold with fever, positive congenital malformations family history, preference of eating pickled vegetables, negative life events during pregnancy, and paternal exposure to poisonous chemicals were the key risk factor, contributing to CNS congenital malformations. while maternal exposure to big consumption of meat，eggs,beans and milk during pregnancy was protective factors that reducing CNS congenital malformation. |
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