| 郑国华,李颢,范万滕,李会庆.大蒜素和硒预防消化道肿瘤的远期效果观察[J].Chinese journal of Epidemiology,2005,26(2):110-112 |
| 大蒜素和硒预防消化道肿瘤的远期效果观察 |
| Study on the long-time effect on allitridum and selenium in prevention of digestive system cancers |
| Received:June 17, 2004 |
| DOI： |
| KeyWord: 消化道肿瘤 大蒜素 硒 效果评价 |
| English Key Word: Cancer of digestive system Allitridum Selenium Evaluation |
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| Abstract: |
| 目的 评价大蒜素、硒预防消化道肿瘤的远期效果。方法 以 1989- 1991年在山东省胃癌高发区栖霞县进行的服用大蒜素、硒预防胃癌的干预研究的队列为对象,随访到 2001年收集各种死因死亡及相关资料,分析其预防消化道肿瘤的远期效果。结果 停药后 5年 (1992 - 1996年 )干预组总肿瘤和消化道肿瘤的累积死亡率相比于对照组分别下降了 4 5 .5 %和 4 1.2 %,其中胃癌下降6 3.6 %。经分层分析,干预组男性相应的累积死亡率比对照组分别下降 5 1.5 %、5 1.5 %和 6 7.7%,相对危险度分别为对照组的 0 .4 8、0 .4 7和 0 .30倍,差异有统计学意义;干预组女性相对危险度分别为对照组的 0 .74、0 .92和 0 .70倍,差异未见统计学意义。停药后 6 - 10年 (1997- 2001年 )两组男女性各类癌症累积死亡率差异无统计学意义。结论 服用大蒜素、硒能有效预防消化道肿瘤的发生,其保护率可达5 0 %并维持到停药后 5年。 |
| English Abstract: |
| Objective To evaluate the long-time effect on allitridum and selenium in preventing cancer of digestive system. Methods Persons who were recruited into the intervention group and took allitridum and selenium to prevent gastric cancer in Qixia county of China from 1989-1991 were followed up to 2001 and data of deaths was collected. The long effect on allitridum and selenium in preventing cancer of digestive system was analysed. Results Data were compared to placebo group five years(1992-1996) after the termination of intervention to have found that the accumulative mortality rate of all cancer,digestive system cancer and gastric cancer had decreased 45.5 %, 41.2 % and 63.3 % in the intervention group respectively. By stratum analysis,accumulative mortality rate of all cancer,digestive system cancer and gastric cancer had decreased 51.5 %, 51.5 % and 67.7 % in males of the intervention group,respectively. Relative risks for males in the intervention group were 0.48, 0.47 and 0.30 times more than the placebo group, respectively. All of them were statistically significant. Relative risks for females in the intervention group were 0.74, 0.92 and 0.70 times more than placebo group.Six to ten years later after the termination of intervention,the accumulative mortality rate and relative risk of all cancers in two groups became similar. Conclusion Allitridum and selenium had the effect of decreasing the incidence risk of digestive cancer with a protective rate more than 50% for five years after the termination of intervention program. |
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