| 文革生,黄永坤,郝萍,李海林,戚勤,周丽芳.云南省昆明市汉族儿童幽门螺杆菌感染HLA-DRB1、DQB1免疫遗传学分析[J].Chinese journal of Epidemiology,2005,26(4):286-289 |
| 云南省昆明市汉族儿童幽门螺杆菌感染HLA-DRB1、DQB1免疫遗传学分析 |
| Immunogenetic analysis of human leukocyte antigen DRB1, DQB1 locus among Han ethnic children with Helicobacter pylori infection in Kunming |
| Received:April 28, 2004 |
| DOI： |
| KeyWord: 螺杆菌 幽门 感染 免疫遗传特征 |
| English Key Word: Helicobacter pylori Infection Immunogenetic features |
| FundProject:云南省教育厅研究基金资助项目(02ZY237) |
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| Abstract: |
| 目的探讨昆明市汉族幽门螺杆菌感染儿童HLADRB1、DQB1免疫遗传学特征。方法应用聚合酶链反应序列特异性引物方法,对35例昆明市汉族儿童幽门螺杆菌感染(实验组)和37名汉族健康儿童(对照组)进行HLADRB1、DQB1基因分型。结果实验组幽门螺杆菌感染HLADRB10901、DQB103032基因频率明显低于对照组健康儿童(7.14%vs.31.08%,χ2=13.16,Pc<0.012;5.71%vs.25.68%,χ2=10.68,Pc=0.007)。其余等位基因的频率比较均无明显的差异。结论HLADRB10901、DQB103032基因可能是昆明汉族儿童抵抗幽门螺杆菌感染的保护基因。 |
| English Abstract: |
| Objective To explore the immunogenetic features of human leukocyte antigen DRB1,DQB1 locus and children with Helicobacter pylori(H.pylori) infection in Han ethnic population in Kunming and its association with digestive diseases and H.pylori to better understand the immunogenetic features of the H.pylori infection.Methods Polymerase chain reaction-sequence specific primer(PCR-SSP) method was used to study the HLA-DRB1,DQB1 allelic frequency distribution on 35 children with H.pylori infection and 37 healthy controls in Han ethnic population in Kunming. Results Allelic frequencies of HLA-DRB1*0901,DQB1*03032 in the H.pylori infection group were lower than those of the healthy control group( 7.14 % vs. 31.08 %, χ2= 13.16, Pc 0.012 ; 5.71 % vs. 25.68 %, χ2= 10.68, Pc= 0.007 ) but the rest alleles' frequencies did not show significant differences.Conclusion These result suggested that HLA-DRB1*0901,DQB1*03032 might protect the H.pylori infection in Han ethnic population in Kunming. |
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