| 梁晓峰,陈园生,王晓军,贺雄,陈丽娟,王骏,林长缨,白呼群,严俊,崔钢,于竞进.中国3岁以上人群乙型肝炎血清流行病学研究[J].Chinese journal of Epidemiology,2005,26(9):655-658 |
| 中国3岁以上人群乙型肝炎血清流行病学研究 |
| A study on the sero-epidemiology of hepatitis B in Chinese population aged over 3-years old |
| Received:March 09, 2005 |
| DOI： |
| KeyWord: 乙型肝炎 血清流行病学 乙型肝炎疫苗 免疫接种 |
| English Key Word: Hepatitis B Sero-epidemiology Hepatitis B vaccine Vaccinate |
| FundProject: |
| Author Name | Affiliation | | LIANG Xiao-feng | Chinese Center for Disease Control and Prevention, Beijing 100050,China | | CHEN Yuan-sheng | Chinese Center for Disease Control and Prevention, Beijing 100050,China | | WANG Xiao-jun | Chinese Center for Disease Control and Prevention, Beijing 100050,China | | HE Xiong | 北京市疾病预防控制中心 | | CHEN Li-juan | 北京市疾病预防控制中心 | | WANG Jun | Chinese Center for Disease Control and Prevention, Beijing 100050,China | | LIN Chang-ying | Chinese Center for Disease Control and Prevention, Beijing 100050,China | | BAI Hu-qun | 卫生部疾病控制司 | | YAN Jun | 卫生部疾病控制司 | | CUI Gang | 卫生部疾病控制司 | | YU Jing-jin | 卫生部疾病控制司 |
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| Abstract: |
| 目的 了解中国现阶段乙型肝炎(乙肝)病毒(HBV)感染现状和评价自1992年乙肝疫苗纳入儿童免疫策略所取得效果。方法 利用中国疾病预防控制中心“2002年中国居民营养与健康状况调查”保留的血清开展乙肝血清学检测。以美国Abbott乙肝酶联免疫吸附试验(ELISA)试剂为金标准选择中国乙肝ELISA检测试剂,并用固相放射免疫方法校对检测结果。结果 中国≥3岁人群HBsAg阳性率、抗-HBs阳性率、HBV流行率经调整后分别为9.09%、37.48%、50.04%;3～12岁儿童分别为5.03%、45.33%、29.10%。≥3岁城市人群HBsAg阳性率、HBV流行率分别为4.61%、43.51%,农村人群分别为9.41%、56.77%。3～12岁城市儿童HBsAg阳性率、HBV流行率分别为2.10%、20.45%,农村儿童分别为8.25%、39.22%。结论 中国≥3岁人群乙肝流行病学特征已发生改变,乙肝疫苗纳入儿童免疫规划效果显著,人群HBsng阳性率、HBV流行率均有不同程度下降, 3～12岁儿童下降更为明显。 |
| English Abstract: |
| Objective To better understand and measure the impact from immunization activities over the last 10-years, we conducted a seroepidemiological study using the remaining blood samples of a nationwide survey on Nutrition and Health in Chinese residents, in 2002. Methods HBsAg, anti-HBs and anti-HBc in blood samples were tested using enzyme-linked immunosorbent assay (ELISA) reagents and revised by solid phase radioimmunoassay and Abbott ELISA reagents. Results Among population older than 3 years, the prevalence rates of HBsAg, anti-HBs and hepatitis B virus(HBV) infection were 9.09%, 37.48% and 50.04% but for children between 3 and 12 year olds, they were 5.03%, 45.33% and 29.10% respectively. Among population older than 3 years, the rates of HBsAg and HBV infection in urban area were4.61 % and 43.51%,but the rates in rural area were 9.41 % and 56.77% respectively while for children from 3-years to 12-years old, they rates were 2.10%, 20.45% in urban area and 8.25%, 39.22% in rural areas, respectively. Conclusion Results revealed that since the hepatitis B vaccine was introduced into the expanded program on immunization(EPI) from 1992,the prevalence rates of HBsAg and HBV infection, especially in the children from 3 to 12 years of age, had obviously declined, suggesting that some changes had happened in the epidemic characters of hepatitis B in China. |
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