| 张文彤,姜庆五.全球历年人甲型流感病毒H3A1抗原的分子进化研究[J].Chinese journal of Epidemiology,2005,26(11):843-847 |
| 全球历年人甲型流感病毒H3A1抗原的分子进化研究 |
| Phylogenetic analysis for H3A1 strain of all human influenza A virus |
| Received:July 14, 2005 |
| DOI： |
| KeyWord: 甲型流感病毒 血凝素 生物信息学 两步聚类法 进化树 |
| English Key Word: Influenza A virus Hemagglutinin Bioinformatics Two-step cluster Phylogenetic tree |
| FundProject:国家自然科学基金资助项目(30400370) |
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| Abstract: |
| 目的 应用生物信息学数据库和工具, 对现有的H3N2亚型人甲型流感病毒全球分离株的H3A1抗原序列进化规律进行分析研究. 方法 下载NCBI Genbank和流感病毒数据库中全部的甲型流感病毒H3A1序列, 首先用两步聚类法进行样本拆分, 随后分类绘制出完整的进化树. 结果 人H3A1序列呈现出单一主干的进化趋势, 随着时间的推移, 进化树结构和进化模型相关参数均呈现出一定的变化规律, 关键变异株的出现则无明显的地域分布特征. 结论 人流感病毒H3A1抗原的进化主要是病毒抗原漂移和人类免疫选择相互作用的结果, 新变异株的出现并未出现明显的地域倾向性, 中国华南地区不应当被认为是H3亚型新变异株的发源地. |
| English Abstract: |
| Objective Influenza A virus remains an important pathogen which threatens humans. With the help of latest developed bioinformatics tools, all available human Influenza A virus H3A1 strains were explored to deeply understanding its evolution and variation rules. Methods All data of H3A1 sequence in NCBI Genbank and Influenza sequence database were downloaded and aligned in ClustalX with two step cluster method used to split the data and Bayesian phylogenetic tree analysis method applied to precisely construct phylogenetic tree for each clusters. Results Tree topology indicated that H3 strains evolved along a single evolution trunk and tree pattern and model parameter showed obvious variety tendency with time period. However, no geographic distribution features were found for key variation strains and big branch in trees. Conclusion The evolution of human H3 strains were mainly driven by the interaction of human immune barriers and antigenic drift of virus. Since the influenza subtype had already been spread in human population, south China should not be considered as the originated areas of new strains, hence it should be treated as equally as other places in the world. |
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